Results 201 to 210 of about 288,483 (243)

Meme biosynthesis in sideroblastic anemia

International Journal of Biochemistry, 1980
Abstract The activities of δ-aminolevulinic acid synthase (ALA-S), δ-aminolevulinic acid dehydratase (ALA-D), uroporphyrinogen I synthase (Uro-I-S), uroporphyrinogen decarboxylase (Uro-DC) and heme synthase have been studied in peripheral red blood cells of 9 patients with hereditary sideroblastic anemia (HSA) and 8 patients with refractory ...
Pekka Vuopio, Mirjam Salmi, Raimo Tenhunen, Aarne V.O. Fasanen   +3 more
openaire   +3 more sources

Refractory anemia with ring sideroblasts

Best Practice & Research Clinical Haematology, 2013
Refractory anemia with ring sideroblasts (RARS) is a subtype of myelodysplastic syndrome (MDS) characterized by 15% or more ring sideroblasts in the bone marrow according to the WHO classification. After Perls staining, ring sideroblasts are defined as erythroblasts in which there are 5 or more siderotic granules covering at least a third of the ...
MALCOVATI, LUCA, CAZZOLA, MARIO
openaire   +4 more sources

Sideroblastic anemia and development of leukemia

Blut, 1981
In patients with refractory anemia it is important to count and classify the different sideroblasts (intermediate sideroblasts with more than six iron grains or ring sideroblasts), to study the cellularity of the bone marrow and disturbances in thrombo- and myelopoiesis, and to note previous exposure to mutagenic or other toxic agents.
Robert Hast, Peter Reizenstein
openaire   +3 more sources

A phenotypic expansion of TRNT1 associated sideroblastic anemia with immunodeficiency, fevers, and developmental delay

American Journal of Medical Genetics. Part A, 2021
Sideroblastic anemia with immunodeficiency, fevers, and developmental delay (SIFD; MIM #616084) is an autosomal recessive disorder of mitochondrial and cytosolic tRNA processing caused by pathogenic, biallelic variants in TRNT1.
J. Odom, H. Amin, Charul Gijavanekar, S. Elsea, S. Kralik, J. Chinen, Yuezhen Lin, Amber M Yates, Elizabeth Mizerik, L. Potocki, F. Scaglia   +10 more
semanticscholar   +1 more source

Zinc abuse and sideroblastic anemia

American Journal of Hematology, 1993
AbstractWe report the case of a young woman who presented with anemia and leukopenia. A bone marrow aspirate, revealed a marked excess of ringed sideroblasts. A detailed dietary history disclosed excessive zinc intake. High serum zinc and low serum copper concentrations were confirmed.
Margaret Telfer, Charles Shapiro, Mark Kozloff, Jayanthi Ramadurai   +3 more
openaire   +3 more sources

Cytogenetic studies in sideroblastic anemia

Cancer, 1976
Cytogenetic studies were performed on bone marrow aspirates from seven patients with acquired sideroblastic anemia. In one male patient a 45,X cell line was present in each of three bone marrow aspirates. The remaining six patients had a normal chromosome complement. The abnormal stem line in the bone marrow may be unrelated to the hematologic disorder
Mogens Krogh Jensen, Margareta Mikkelsen
openaire   +3 more sources

A synonymous coding variant that alters ALAS2 splicing and causes X‐linked sideroblastic anemia

Pediatric Blood & Cancer, 2021
To the Editor: X-linkedsideroblastic anemia (XLSA) is the most common form of congenital sideroblastic anemia (CSA). Approximately 70 different mutations have been described.
Jamie Oakley, D. Campagna, Liang Sun, S. Rockowitz, P. Śliż, J. Boudreaux, G. Woods, M. Fleming   +7 more
semanticscholar   +1 more source

Busulfan‐induced sideroblastic anemia

American Journal of Hematology, 1988
AbstractPatients in the stable phase of chronic myelogenous leukemia (CML) are usually treated with busulfan. The bone marrow of patients with CML may be exquisitely sensitive to busulfan, and occasionally such patients develop pancytopenia, secondary to hypoplasia or aplasia of the bone marrow, which is presumed to be due to busulfan‐induced marrow ...
Louis A. Fernandez, Ekram Zayed
openaire   +3 more sources

[Pathophysiology of sideroblastic anemia].

[Rinsho ketsueki] The Japanese journal of clinical hematology
Sideroblastic anemias (SAs) are a diverse group of congenital and acquired disorders, characterized by anemia and the presence of ring sideroblasts in bone marrow.
Tohru Fujiwara
semanticscholar   +1 more source

Sideroblastic anemia terminating in myelofibrosis

American Journal of Hematology, 1982
AbstractTwo patients with primary acquired sideroblastic anemia who eventually developed myelofibrosis with myeloid metaplasia are reported. Splenectomy was performed in one patient because of increasing blood transfusion requirements, and splenic histology revealed both myeloid metaplasia and ringed sideroblasts.
Maurice M. Albala, Joseph A. Grasso, Thomas J. Myers, Daniel F. Lukowicz   +3 more
openaire   +3 more sources