Results 211 to 220 of about 288,483 (243)

Mitochondrial myopathy and sideroblastic anemia

American Journal of Medical Genetics Part A, 2003
AbstractWe report four new cases of mitochondrial myopathy and sideroblastic anemia (MSA). Hallmark features of MSA include progressive exercise intolerance during childhood, onset of sideroblastic anemia around adolescence, basal lactic acidemia, and mitochondrial myopathy.
Kari Casas, Nathan Fischel-Ghodsian
openaire   +3 more sources

The molecular basis of the sideroblastic anemias

Current Opinion in Hematology, 1996
The sideroblastic anemias display remarkable clinical and hematologic heterogeneity but share in common mitochondrial iron loading as evidence of unhinging between intracellular iron metabolism and heme biosynthesis. Molecular defects responsible for this unhinging have now been identified and appear to display matching heterogeneity.
Alison May, Edward J. Fitzsimons
openaire   +3 more sources

Sideroblastic Anemia in an Elderly Patient

Journal of the American Geriatrics Society, 1977
ABSTRACTA 91‐year‐old man had been treated for iron‐deficiency anemia for four years before admission to the Geriatric Unit of the Hasharon Hospital because of cardiac insufficiency and epigastric pain. In the Unit, laboratory studies revealed, in addition to hypochromic anemia, a high level of plasma iron and a reduced iron‐binding capacity.
N. Himmelstein, I. Sirkis, Z. Strauss
openaire   +3 more sources

Clinical characterization and hematopoietic stem cell transplant outcomes for congenital sideroblastic anemia caused by a novel pathogenic variant in SLC25A38

Pediatric Blood & Cancer, 2020
Congenital sideroblastic anemia (CSA) constitutes an uncommon category of inherited anemia often associated with pathologic iron accumulation. Pathogenic variants in several genes have been identified as causative for CSA.
K. Uminski, D. Houston, J. N. Hartley, Jing Liu, G. Cuvelier, S. Israels   +5 more
semanticscholar   +1 more source

Treatment of Sideroblastic Anemia with Chloroquine

New England Journal of Medicine, 1995
To the Editor: The mainstay of treatment for sideroblastic anemia, a group of heterogeneous disorders1,2 involving a defect in heme synthesis,3 is transfusion. We describe a 19-year-old man with sideroblastic anemia who was successfully treated with chloroquine. The patient was referred to our institution in 1984 because of anemia. The white-cell count
Bruno Turlin, Dominique Guyader, Renée Fauchet, Bernard Drenou   +3 more
openaire   +2 more sources

Biology of sideroblastic anemia.

[Rinsho ketsueki] The Japanese journal of clinical hematology, 2017
Sideroblastic anemia is characterized by anemia with ring sideroblasts produced by the bone marrow. Sideroblasts are formed by disutilization and deposit of iron in the mitochondoria. There are two forms of sideroblastic anemia: congenital and acquired.
openaire   +3 more sources

Mitochondrial Iron Metabolism and Sideroblastic Anemia

Acta Haematologica, 2009
Sideroblastic anemias are a heterogeneous group of disorders, characterized by mitochondrial iron overload in developing red blood cells. The unifying characteristic of all sideroblastic anemias is the ring sideroblast, which is a pathological erythroid precursor containing excessive deposits of non-heme iron in mitochondria with perinuclear ...
Prem Ponka, Alex D. Sheftel, Josef T. Prchal, Des R. Richardson   +3 more
openaire   +2 more sources

The genetics of inherited sideroblastic anemias

Seminars in Hematology, 2002
The sideroblastic anemias are a heterogeneous group of acquired and inherited bone marrow disorders defined by the presence of pathologic iron deposits in erythroblast mitochondria. While the pathogenesis of almost all cases of acquired sideroblastic anemia is unknown, the molecular genetic basis for several of the inherited forms have now been ...
openaire   +3 more sources

Sideroblastic anemia secondary to zinc toxicity

Blood, 2013
![Figure][1] A 52-year-old African-American woman with a history of allergic rhinitis and alcohol abuse presented with a presyncope. The following levels were found: hemoglobin, 3.7 g/dL; mean cell volume, 82 fL; white blood cell count, 9.2 × 103/μL; and platelets, 168 × 103/μL ...
Yaser Alkhatib, Jawad Sheqwara
openaire   +3 more sources

ERYTHREMIA WITH SPECIAL REFERENCE TO SIDEROBLASTIC ANEMIA

Acta Pathologica Japonica, 1980
An autopsy case of erythremia with sideroblastic tumor cell proliferation is described. A 60‐year‐old man was admitted to the hospital due to general fatigue and anorexia. Bone marrow aspiration revealed abnormalities in erythropoiesis (megaloblasts, 4%; sideroblasts, 84%; ring‐formed, 39%, and PAS‐positive, 5%).
Toyohiko Taki, Hidemasa Kishimoto, Takashi Wakabayashi   +2 more
openaire   +3 more sources