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Siderophore conjugates

Annals of the New York Academy of Sciences, 2013
There has been considerable effort expended in the investigation of the potential of siderophore conjugates of antibiotics to circumvent the permeability barrier imposed by the outer membrane of Gram‐negative bacteria. There is also a small group of natural conjugates, the sideromycins.
Malcolm G P Page
exaly   +3 more sources

Engineering siderophores

2020
Siderophores have important functions for bacteria in iron acquisition and as virulence factors. In this chapter we will discuss the engineering of cyclic hydroxamate siderophores by various biochemical approaches based on the example of Shewanella algae. The marine gamma-proteobacterium S. algae produces three different cyclic hydroxamate siderophores
Sina, Rütschlin, Thomas, Böttcher
openaire   +2 more sources

Peptide siderophores

Journal of Peptide Science, 1998
Siderophores are low molecular weight iron chelators, produced by virtually all bacteria, fungi and some plants. They serve to deliver the essential element iron, barely soluble under aerobic conditions, into microbial cells. Siderophores are therefore important secondary metabolites which are very often based on amino acids and their derivatives ...
H, Drechsel, G, Jung
openaire   +2 more sources

Cefiderocol: A Siderophore Cephalosporin

Annals of Pharmacotherapy, 2020
Objective: This article reviews the available data on the chemistry, spectrum of activity, pharmacokinetic and pharmacodynamic properties, clinical efficacy, and potential place in therapy of cefiderocol. Data Sources: A literature search through PubMed, Google Scholar, and ClinicalTrials.gov was conducted (2009 to March 2020) using the search terms ...
Rania M. El-Lababidi, John George Rizk
openaire   +2 more sources

Siderophores

Archives of Biochemistry and Biophysics, 1981
Siderophores, defined as low-iron-induced virtually ferric-specific ligands, are widely distributed in microbial species where they function in the sequestration and transport of iron. In Escherichia coli biosynthesis of siderophores is negatively regulated at the transcriptional level by ferrous ion in conjunction with a repressor protein, Fur (ferric
openaire   +3 more sources

Siderophore production by actinobacteria

BioMetals, 2014
Produced by bacteria, fungi and plants, siderophores are low-molecular-weight chelating agents (200-2,000 Da) to facilitate uptake of iron (Fe). They play an important role in extracellular Fe solubilization from minerals to make it available to microorganisms.
Wenfeng, Wang   +3 more
openaire   +2 more sources

Siderophore sorption to clays

BioMetals, 2009
Siderophores are low molecular weight organic ligands exuded by some aerobic organisms and plants to acquire Fe under Fe-limited conditions. The hydroxamate siderophores may sorb to aluminosilicate clays through a variety of mechanisms depending upon the nature of the clay and of the siderophore along with solution conditions such as pH, ionic strength,
Patricia A, Maurice   +2 more
openaire   +2 more sources

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