Results 41 to 50 of about 117,129 (265)

A Disturbed Siderophore Transport Inhibits Myxobacterial Predation

, 2022
Background: Understanding the intrinsic mechanisms of bacterial competition is a fundamental question. Iron is an essential trace nutrient that bacteria compete for.
Honghong Dong, Dong, Honghong, Honghui Zhu, Yao, Qing, Dong, Yijie, Qing Yao, Feng, Zengwei, Xing Wang, Zengwei Feng, Wang, Xing, Zhu, Honghui, Yijie Dong   +11 more
core   +1 more source

Disrupting Helicobacter pylori Iron Homeostasis With Bismuth Nanodrug‐Mediated Nutritional Trap for Targeted Gastric Infection Therapy

Advanced Science, EarlyView.
A “nutritional trap” strategy centered on disrupting bacterial iron homeostasis is proposed. The synthesized Bi‐TP@FU (TBF) can target Helicobacter pylori, interfere with the bacterial iron uptake and utilization processes to disrupt its iron homeostasis, induce bacterial death, and meanwhile preserve the balance of the intestinal flora.
Tianye Fang, Jinzhe Tong, Feng Feng, Cong Liu, Chang Shu, Jiaying Zhu, Shibo Zhang, Shuyue Deng, Wanchao Zuo, Yuhan Song, Jun Yang, Yanmin Ju, Yingying Xing, Jianjun Dai   +13 more
wiley   +1 more source

Metabolomic analysis of siderophore cheater mutants reveals metabolic costs of expression in uropathogenic escherichia coli [PDF]

, 2014
Bacterial siderophores are a group of chemically diverse, virulence-associated secondary metabolites whose expression exerts metabolic costs. A combined bacterial genetic and metabolomic approach revealed differential metabolomic impacts associated with ...
Hung, Chia S., Henderson, Jeffrey P., Lv, Haitao   +2 more
core   +1 more source

Unveiling the Taxonomic Diversity and Unprecedented Biosynthetic Treasure of the Phylum Myxococcota

Advanced Science, EarlyView.
Natural products remain vital sources of therapeutics, and the phylum Myxococcota constitutes an especially rich reservoir for them. Based on decades of microbiological efforts, we present 154 new Myxococcota genomes and revise taxonomy quadrupling the number of families and genera.
Amay Ajaykumar Agrawal, Ronald Garcia, Guangyi Chen, Chantal D. Bader, Peter Sullivan, Alexander Popoff, Daniel Krug, Maja Hunter, Sebastian Walesch, Emilia Oueis, Christine Frank, Haowen Zhao, Joachim J. Hug, Sebastian Keller, Pascal Hirsch, Azat Tagirdzhanov, Tatiana Malygina, Mary Victory E. Gutierrez, Alexey Gurevich, Judith Boldt, Boyke Bunk, Jörg Overmann, Ulrich Nübel, Andreas Keller, Olga V. Kalinina, Rolf Müller   +25 more
wiley   +1 more source

Identification and characterisation of novel iron acquisition mechanisms in Sinorhizobium meliloti 2011 and Pseudomonas aeruginosa [PDF]

, 2003
All known microorganisms with the exception of lactobacilli display an absolute requirement for iron. Although iron is the fourth most abundant element on earth, it is rapidly oxidised at neutral pH forming insoluble hydroxides.
Ó Cuív, Páraic
core   +1 more source

Optimization, characterization and biological activity of siderophore produced by marine Streptomyces coelicolor.

PLoS ONE
Two Streptomyces spp. were isolated from open ocean waters of the Gulf of Mannar. Of the two isolates, one was identified as Streptomyces coelicolor through conventional and molecular approaches, and it was found to produce a siderophore ...
Benazir Begum Sirajudeen, Jenifer Annis Christy Joseph Sahayaraj, Lok Kirubahar Sankararamalingam, Raja Roobia Rajendran, Murugappan Ramanathan, Padmavathy Sethuramasamy   +5 more
doaj   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

Differences in Siderophore Production During the Growth of Phytoplankton in Southern Ocean Incubation Experiments Under High- and Low-Iron Conditions. [PDF]

Environ Microbiol
Experiments performed in the Southern Ocean under low‐ and high‐iron conditions showed that the heterotrophic bacteria community produced distinct iron‐binding compounds called siderophores, depending on the environmental conditions, despite similar bacteria communities being present in each experiment.
Bundy RM, Buck KN, Jenkins BD, Chappell PD, Repeta DJ, Sterling A, Yang SM, Holland L, Mahieu L, Moore LE.   +9 more
europepmc   +2 more sources

Structural and Functional Siderophore Remodeling by Enzymatic Delipidation. [PDF]

Angew Chem Int Ed Engl
A surprising functional switch in bacterial siderophores was discovered through genome mining and the analysis of environmental and pathogenic Pandoraea species. Pandorachelin B, a lipocyclopeptide that promotes swarming motility, is cleaved by a specialized acylase, yielding a ring‐contracted, homodetic cyclopeptide, pandorachelin A, which exhibits ...
Herzog E, Ishida K, Molloy EM, Hermenau R, Scherlach K, Hertweck C.   +5 more
europepmc   +3 more sources

Programming Gut Microbiome Function Through Cross‐Feeding: From Ecological Mechanisms to Live Biotherapeutics

Advanced Science, EarlyView.
This graphical abstract presents gut microbial cross‐feeding through a Mechanism–Technology–Application framework. It summarizes major resource‐transfer modes, the experimental and computational tools used to establish causality, and potential interventions involving dietary substrates, live biotherapeutic products, and engineered microbes.
Chuankai Sun, Teng Ma, Hao Jin, Zelong Li, Yi Cheng, Jingjin Li, Lai‐Yu Kwok, Zhihong Sun   +7 more
wiley   +1 more source