Results 1 to 10 of about 2,715 (160)

Transition-Metal-Based Dearomatization Strategy for the Synthesis of Functionalized <i>cis</i>-Tetrahydro-2-Oxindoles. [PDF]

Organometallics
cis-Tetrahydro-2-oxindoles are valuable scaffolds in medicinal chemistry. Herein, we report a transition-metal-mediated dearomatization strategy to access these compounds. The process begins with the coordination of a phenyl sulfone by a tungsten complex
Siano P, Diment LA, Siela DJ, Ericson MN, McGraw M, Song BC, Livaudais BF, Simpson SR, Dickie DA, Harman WD.   +9 more
europepmc   +2 more sources

An organometallic approach to the synthesis of heteropolycyclic compounds from benzenes. [PDF]

Nat Commun
The emerging field of dearomatization capitalizes on the synthetic potential of aromatic molecules. By using a transition metal to bind to two carbons of a benzene ring, the remaining four carbons are left available for the attachment of various chemical
Siano P, Diment LA, Siela DJ, Ericson MN, McGraw M, Livaudais BF, Dickie DA, Harman WD.   +7 more
europepmc   +2 more sources

Tungsten-anisole complex provides 3,6-substituted cyclohexenes for highly diversified chemical libraries. [PDF]

Sci Adv
Medicinal chemists use vast combinatorial molecular libraries to develop leads for new pharmaceuticals. The syntheses of these compounds typically rely on coupling molecular fragments through atoms with planar (sp2) geometry.
Weatherford-Pratt JT, Bloch JM, Smith JA, Ericson MN, Siela DJ, Ortiz MR, Shingler MH, Fong S, Laredo JA, Patel IU, McGraw M, Dickie DA, Harman WD.   +12 more
europepmc   +2 more sources

The cacao gene atlas: a transcriptome developmental atlas reveals highly tissue-specific and dynamically-regulated gene networks in Theobroma cacao L. [PDF]

BMC Plant Biol
Theobroma cacao, the cocoa tree, is a tropical crop grown for its highly valuable cocoa solids and fat which are the basis of a 200-billion-dollar annual chocolate industry.
Kulesza E, Thomas P, Prewitt SF, Shalit-Kaneh A, Wafula E, Knollenberg B, Winters N, Esteban E, Pasha A, Provart N, Praul C, Landherr L, dePamphilis C, Maximova SN, Guiltinan MJ.   +14 more
europepmc   +2 more sources

Pervasive effects of a dominant foliar endophytic fungus on host genetic and phenotypic expression in a tropical tree. [PDF]

Front Microbiol, 2014
It is increasingly recognized that macro-organisms (corals, insects, plants, vertebrates) consist of both host tissues and multiple microbial symbionts that play essential roles in their host's ecological and evolutionary success.
Mejía LC, Herre EA, Sparks JP, Winter K, García MN, Van Bael SA, Stitt J, Shi Z, Zhang Y, Guiltinan MJ, Maximova SN.   +10 more
europepmc   +2 more sources

Developing a core collection for the conservation of Theobroma cacao's genetic diversity. [PDF]

BMC Genomics
Crop core collections serve as a means of conserving genetic variation and providing a diverse array of accessions for future research and breeding endeavours.
Todd ET, Arigoni F, Holzwarth JA, Bellanger L, Descombes P, Beche E, Lass T, Guiltinan MJ, Maximova SN, Leandro M, Mérot V, Lepelley M, Fillodeau A.   +12 more
europepmc   +2 more sources

Reduced Susceptibility to Phytophthora in Non‐Transgenic Cacao Progeny Through CRISPR–Cas9 Mediated TcNPR3 Mutagenesis

Plant Biotechnology Journal, EarlyView.
ABSTRACT Black pod disease, caused by a complex of Phytophthora species, poses a severe threat to global cacao production. This study explores the use of CRISPR–Cas9 genome editing to reduce disease susceptibility in Theobroma cacao L. by targeting the TcNPR3 gene, a known negative regulator of plant defence.
Mark J. Guiltinan, Lena Landherr, Siela N. Maximova, Dante DelVecchio, Aswathy Sebastian, Istvan Albert   +5 more
wiley   +2 more sources

SIELA 2020 Content [PDF]

2020 21st International Symposium on Electrical Apparatus & Technologies (SIELA), 2020
openaire   +2 more sources

SIELA 2020 Author Index [PDF]

2020 21st International Symposium on Electrical Apparatus & Technologies (SIELA), 2020
openaire   +2 more sources

A combination of conserved and diverged responses underlies Theobroma cacao's defense response to Phytophthora palmivora. [PDF]

BMC Biol
Plants have complex and dynamic immune systems that have evolved to resist pathogens. Humans have worked to enhance these defenses in crops through breeding.
Winters NP, Wafula EK, Knollenberg BJ, Hämälä T, Timilsena PR, Perryman M, Zhang D, Sheaffer LL, Praul CA, Ralph PE, Prewitt S, Leandro-Muñoz ME, Delgadillo-Duran DA, Altman NS, Tiffin P, Maximova SN, dePamphilis CW, Marden JH, Guiltinan MJ.   +18 more
europepmc   +2 more sources