Results 1 to 10 of about 590 (178)

Synthesis of Sulfur Enriched Cyclohexenes via the Tungsten-Promoted Dearomatization of a Phenyl Sulfone. [PDF]

European J Org Chem
A method for synthesizing sulfur‐substituted cyclohexenes is reportedthat leverages the η2‐coordination of a phenyl sulfone to [WTp(NO)(PMe3)] (Tp = trispyrazolylborate). Three sequential protonation and nucleophilic additions to the bound arene, followed by oxidative decomplexation, affords functionalized cyclohexenes bearing sp3‐ and sulfur‐enriched ...
Siela DJ, McGraw MC, Dickie DA, Harman WD.   +3 more
europepmc   +2 more sources

Reduced Susceptibility to Phytophthora in Non-Transgenic Cacao Progeny Through CRISPR-Cas9 Mediated TcNPR3 Mutagenesis. [PDF]

Plant Biotechnol J
ABSTRACT Black pod disease, caused by a complex of Phytophthora species, poses a severe threat to global cacao production. This study explores the use of CRISPR–Cas9 genome editing to reduce disease susceptibility in Theobroma cacao L. by targeting the TcNPR3 gene, a known negative regulator of plant defence.
Guiltinan MJ, Landherr L, Maximova SN, DelVecchio D, Sebastian A, Albert I.   +5 more
europepmc   +2 more sources

ELABELA Targets Mitochondria to Modulate Heart Development. [PDF]

Adv Sci (Weinh)
The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Wang J, Wang Q, Xu Z, Zhou S, Zhou Y, Yang J, Tong L, Meng Z, Yang M, Zhao W, Yang T, Wang H, Zhang J, Tan R, Wang L, Huang Y, Zhou B, Chen S, Zhang B, Yuan J, Zhao J, Chen AF, Sun K.   +22 more
europepmc   +2 more sources

Transient Expression of CRISPR/Cas9 Machinery Targeting TcNPR3 Enhances Defense Response in Theobroma cacao [PDF]

Frontiers in Plant Science, 2018
Theobroma cacao, the source of cocoa, suffers significant losses to a variety of pathogens resulting in reduced incomes for millions of farmers in developing countries.
Andrew S. Fister, Lena Landherr, Siela N. Maximova, Siela N. Maximova, Mark J. Guiltinan, Mark J. Guiltinan   +5 more
doaj   +2 more sources

Clovamide, a Hydroxycinnamic Acid Amide, Is a Resistance Factor Against Phytophthora spp. in Theobroma cacao [PDF]

Frontiers in Plant Science, 2020
The hydroxycinnamic acid amides (HCAAs) are a diverse group of plant-specialized phenylpropanoid metabolites distributed widely in the plant kingdom and are known to be involved in tolerance to abiotic and biotic stress. The HCAA clovamide is reported in
Benjamin J. Knollenberg, Benjamin J. Knollenberg, Guo-Xing Li, Joshua D. Lambert, Siela N. Maximova, Siela N. Maximova, Mark J. Guiltinan, Mark J. Guiltinan   +7 more
doaj   +2 more sources

Transcriptomic analyses of cacao flavonoids produced in photobioreactors [PDF]

BMC Genomics, 2021
Background Theobroma cacao is a major source of flavonoids such as catechins and their monomers proanthocyanidins (PAs), widely studied for their potential benefits in cardiovascular diseases.
Adriana M. Gallego, Luisa F. Rojas, Wilmar G. Valencia, Lucía Atehortúa, Aura I. Urrea, Andrew S. Fister, Mark J. Guiltinan, Siela N. Maximova, Natalia Pabón-Mora   +8 more
doaj   +2 more sources

Characterization of a stearoyl-acyl carrier protein desaturase gene family from chocolate tree, Theobroma cacao L. [PDF]

Frontiers in Plant Science, 2015
In plants, the conversion of stearoyl-ACP to oleoyol-ACP is catalyzed by a plastid-localized soluble stearoyl-acyl carrier protein (ACP) desaturase (SAD).
Yufan eZhang, Siela N. Maximova, Mark J. Guiltinan   +2 more
doaj   +2 more sources

Glucocorticoid receptor-regulated TcLEC2 expression triggers somatic embryogenesis in Theobroma cacao leaf tissue. [PDF]

PLoS ONE, 2018
Theobroma cacao, the source of cocoa, is a crop of particular importance in many developing countries. Availability of elite planting material is a limiting factor for increasing productivity of Theobroma cacao; therefore, the development of new ...
Andrew S Fister, Lena Landherr, Melanie Perryman, Yufan Zhang, Mark J Guiltinan, Siela N Maximova   +5 more
doaj   +2 more sources

An organometallic approach to the synthesis of heteropolycyclic compounds from benzenes [PDF]

Nature Communications
The emerging field of dearomatization capitalizes on the synthetic potential of aromatic molecules. By using a transition metal to bind to two carbons of a benzene ring, the remaining four carbons are left available for the attachment of various chemical
Paolo Siano, Louis A. Diment, Daniel J. Siela, Megan N. Ericson, Matt McGraw, Benjamin F. Livaudais, Diane A. Dickie, W. Dean Harman   +7 more
doaj   +2 more sources

„FAIDONAS“: Sielos Nemirtingumo Įrodymų Struktūra Ir Prasmė

Problemos, 2005
Straipsnyje analizuojami ir interpretuojami Platono dialoge „Faidonas“ pateikti sielos nemirtingumo įrodymai. Platonas šiame dialoge siekia rekonstruoti sokratiškojo imperatyvo „Pasirūpink savo siela, kad ji taptų kuo geresnė“ prielaidas.
Skirmantas Jankauskas
exaly   +3 more sources