Results 1 to 10 of about 2,787 (195)

Reduced Susceptibility to Phytophthora in Non-Transgenic Cacao Progeny Through CRISPR-Cas9 Mediated TcNPR3 Mutagenesis. [PDF]

Plant Biotechnol J
ABSTRACT Black pod disease, caused by a complex of Phytophthora species, poses a severe threat to global cacao production. This study explores the use of CRISPR–Cas9 genome editing to reduce disease susceptibility in Theobroma cacao L. by targeting the TcNPR3 gene, a known negative regulator of plant defence.
Guiltinan MJ, Landherr L, Maximova SN, DelVecchio D, Sebastian A, Albert I.   +5 more
europepmc   +3 more sources

An organometallic approach to the synthesis of heteropolycyclic compounds from benzenes [PDF]

Nature Communications
The emerging field of dearomatization capitalizes on the synthetic potential of aromatic molecules. By using a transition metal to bind to two carbons of a benzene ring, the remaining four carbons are left available for the attachment of various chemical
Paolo Siano, Louis A. Diment, Daniel J. Siela, Megan N. Ericson, Matt McGraw, Benjamin F. Livaudais, Diane A. Dickie, W. Dean Harman   +7 more
doaj   +3 more sources

Pervasive effects of a dominant foliar endophytic fungus on host genetic and phenotypic expression in a tropical tree [PDF]

Frontiers in Microbiology, 2014
It is increasingly recognized that macro-organisms (corals, insects, plants, vertebrates) consist of both host tissues and multiple microbial symbionts that play essential roles in their host’s ecological and evolutionary success.
Luis C. Mejía, Luis C. Mejía, Edward Allen Herre, Jed P. Sparks, Klaus eWinter, Milton N. García, Sunshine A. Van Bael, Joseph eStitt, Zi eShi, Yufan eZhang, Mark J. Guiltinan, Siela N. Maximova   +11 more
doaj   +3 more sources

Glucocorticoid receptor-regulated TcLEC2 expression triggers somatic embryogenesis in Theobroma cacao leaf tissue. [PDF]

PLoS ONE, 2018
Theobroma cacao, the source of cocoa, is a crop of particular importance in many developing countries. Availability of elite planting material is a limiting factor for increasing productivity of Theobroma cacao; therefore, the development of new ...
Andrew S Fister, Lena Landherr, Melanie Perryman, Yufan Zhang, Mark J Guiltinan, Siela N Maximova   +5 more
doaj   +3 more sources

Morphology of Settlement of the Dayak Kenyah Tribe, Budaya Pampang Village, Samarinda City in a Socio-Cultural Context [PDF]

Local Wisdom, 2023
The Dayak Kenyah community is a dynamic tribe influenced by its socio-cultural context. Socio-cultural changes will affect the form of settlement. This journal focuses on the influence of the socio-cultural context on the settlement morphology of the ...
Siela Mara Nabela, Ema Yunita Titisari, Sri Utami   +2 more
doaj   +2 more sources

Transition-Metal-Based Dearomatization Strategy for the Synthesis of Functionalized <i>cis</i>-Tetrahydro-2-Oxindoles. [PDF]

Organometallics
cis-Tetrahydro-2-oxindoles are valuable scaffolds in medicinal chemistry. Herein, we report a transition-metal-mediated dearomatization strategy to access these compounds. The process begins with the coordination of a phenyl sulfone by a tungsten complex
Siano P, Diment LA, Siela DJ, Ericson MN, McGraw M, Song BC, Livaudais BF, Simpson SR, Dickie DA, Harman WD.   +9 more
europepmc   +2 more sources

Tungsten-anisole complex provides 3,6-substituted cyclohexenes for highly diversified chemical libraries. [PDF]

Sci Adv
Medicinal chemists use vast combinatorial molecular libraries to develop leads for new pharmaceuticals. The syntheses of these compounds typically rely on coupling molecular fragments through atoms with planar (sp2) geometry.
Weatherford-Pratt JT, Bloch JM, Smith JA, Ericson MN, Siela DJ, Ortiz MR, Shingler MH, Fong S, Laredo JA, Patel IU, McGraw M, Dickie DA, Harman WD.   +12 more
europepmc   +2 more sources

Synthesis of Sulfur Enriched Cyclohexenes via the Tungsten‐Promoted Dearomatization of a Phenyl Sulfone

European Journal of Organic Chemistry, Volume 29, Issue 9, 2 March 2026.
A method for synthesizing sulfur‐substituted cyclohexenes is reportedthat leverages the η2‐coordination of a phenyl sulfone to [WTp(NO)(PMe3)] (Tp = trispyrazolylborate). Three sequential protonation and nucleophilic additions to the bound arene, followed by oxidative decomplexation, affords functionalized cyclohexenes bearing sp3‐ and sulfur‐enriched ...
Daniel J. Siela, Matthew C. McGraw, Diane A. Dickie, W. Dean Harman   +3 more
wiley   +2 more sources

Transient Expression of CRISPR/Cas9 Machinery Targeting TcNPR3 Enhances Defense Response in Theobroma cacao [PDF]

Frontiers in Plant Science, 2018
Theobroma cacao, the source of cocoa, suffers significant losses to a variety of pathogens resulting in reduced incomes for millions of farmers in developing countries.
Andrew S. Fister, Lena Landherr, Siela N. Maximova, Siela N. Maximova, Mark J. Guiltinan, Mark J. Guiltinan   +5 more
doaj   +2 more sources

Clovamide, a Hydroxycinnamic Acid Amide, Is a Resistance Factor Against Phytophthora spp. in Theobroma cacao [PDF]

Frontiers in Plant Science, 2020
The hydroxycinnamic acid amides (HCAAs) are a diverse group of plant-specialized phenylpropanoid metabolites distributed widely in the plant kingdom and are known to be involved in tolerance to abiotic and biotic stress. The HCAA clovamide is reported in
Benjamin J. Knollenberg, Benjamin J. Knollenberg, Guo-Xing Li, Joshua D. Lambert, Siela N. Maximova, Siela N. Maximova, Mark J. Guiltinan, Mark J. Guiltinan   +7 more
doaj   +2 more sources