Results 61 to 70 of about 81,129 (305)

Efficient Estimation of Semiparametric Conditional Moment Models with Possibly Nonsmooth Residuals [PDF]

open access: yes
This paper considers semiparametric efficient estimation of conditional moment models with possibly nonsmooth residuals in unknown parametric components (theta) and unknown functions (h) of endogenous variables.
Demian Pouzo, Xiaohong Chen
core   +4 more sources

Electrophysiological approach to determine kinetic parameters of sucrose uptake by single sieve elements or phloem parenchyma cells in intact Vicia faba plants

open access: yesFrontiers in Plant Science, 2013
Apart from a few using cut aphid stylets, no attempts have been made thus far to measure in vivo sucrose-uptake properties of sieve elements. We investigated the kinetics of sucrose uptake by single sieve elements and phloem parenchyma cells in Vicia ...
Jens B. Hafke   +3 more
doaj   +1 more source

Wet Sieve Analysis of Limestone

open access: yesJournal of AOAC INTERNATIONAL, 1972
Abstract A study of wet sieving vs. dry sieving was made on 47 limestone samples. Fifteen samples showed absolute differences of 5% or more on a U.S. No. 40 sieve when the dry samples were not crushed to break agglomerates. Three samples differed by more than 15%.
openaire   +1 more source

Dry sieving analysis of soil by vibratory sieve shaker: modification and optimization

open access: yesDokuchaev Soil Bulletin, 2019
This study performs a methodical experiment on adaptation and unification of soil dry sieving analysis. The analysis is based on the Savvinov dry sieving method that uses 0.5-1.5 kg air-dried soil samples which are passed through the 10, 7, 5, 3, 2, 1, 0.5, 0.25 mm sieves. The studied soils are silt loam Eutric Retisol and Haplic Chernozem.
D. S. Fomin   +3 more
openaire   +3 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Sieve analysis results for extracted aggregates.

open access: yes, 2015
Sieve analysis results for extracted aggregates.
Julide Oner (682793)   +1 more
core   +1 more source

ENSEMBLE Phase 3 Trial Sieve Analysis Statistical Analysis Plan

open access: yes, 2023
This SAP describes the statistical analyses for addressing the sieve analysis exploratory objective in the ENSEMBLE Phase 3 trial, a randomized, placebo-controlled COVID-19 vaccine effi?cacy trial: Exploratory Objective: To evaluate the genetic and/or ...
Allan DeCamp (140048)   +10 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

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