Results 91 to 100 of about 138,604 (330)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Hydroisomerization of n-hexadecane on Pt-containing silicone aluminum phosphate molecular sieves SAPO-11 with different silicon content

Тонкие химические технологии
Objectives. To obtain silicone aluminum phosphate molecular sieves SAPO-11 with different silicon content, to determine their pore space and acidic properties, to apply 0.5 wt % to their surface Pt, and to evaluate the effectiveness of the use of n ...
M. R. Agliullin, A. N. Khazipova, A. F. Akhmetov, O. A. Baulin   +3 more
doaj   +1 more source

Electrochemical Detection of Phenol in Industrial Pollutant Absorbed Molecular Sieves by Electrochemically Activated Screen Printed Carbon Electrode

International Journal of Electrochemical Science, 2015
An electrochemically activated screen printed carbon electrode (EASPCE) was used for the electrochemical detection of phenol in the industrial pollutant absorbed molecular sieves.
Subramanian Sakthinathan, Selvakumar Palanisamy, Shen-Ming Chen, Pei-Shan Wu, Leehter Yao, Bih-Show Lou   +5 more
doaj   +1 more source

Narrow sieves for parameterized paths and packings

, 2010
We present randomized algorithms for some well-studied, hard combinatorial problems: the k-path problem, the p-packing of q-sets problem, and the q-dimensional p-matching problem.
Björklund, Andreas, Husfeldt, Thore, Kaski, Petteri, Koivisto, Mikko   +3 more
core  

This before That: Causal Precedence in the Biomedical Domain

, 2016
Causal precedence between biochemical interactions is crucial in the biomedical domain, because it transforms collections of individual interactions, e.g., bindings and phosphorylations, into the causal mechanisms needed to inform meaningful search and ...
Bell, Dane, Hahn-Powell, Gus, Surdeanu, Mihai, Valenzuela-Escárcega, Marco A.   +3 more
core   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Aspects of energy requirements for rock drilling [PDF]

, 1974
Development of laboratory rock breakage techniques to relate energy and surface area produced by slow compression, drop hammer and stamp mill. A detailed study of laboratory rotary-percussive drilling in a wide range of rocks under different ...
Wootton, David
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Sieve: Actionable Insights from Monitored Metrics in Microservices [PDF]

, 2017
Jörg Thalheim, António Rodrigues, İstemi Ekin Akkuş, Pramod Bhatotia, Ruichuan Chen, Bimal Viswanath, Lei Jiao, Christof Fetzer   +7 more
openalex   +1 more source