Results 51 to 60 of about 941,726 (292)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Sigma Convergence and VECM Approach in Explaining the Relationship among Macro Variables in Indonesia [PDF]

open access: yesGATR Journal of Business and Economics Review, 2019
Objective – Inequality of regional income, government expenditure and government revenue can show the performance of these variables in improving the economic and non-economic conditions of each region. Previous literature discusses, in part, the inequality among these three variables.
Sri Kurniawati, Nindya Lestari
openaire   +1 more source

Stability analysis for a recurrent sigma‒pi‒sigma neural network based on a batch gradient algorithm with L2 regularization [PDF]

open access: yesPeerJ Computer Science
Higher-order neural networks (HONNs) have more powerful nonlinear mapping capabilities than traditional feed-forward neural networks do. The recurrent sigma-pi-sigma neural network (RSPSNN), a multilayer higher-order neural network, suffers from slow ...
Liqing Zhang   +4 more
doaj   +2 more sources

Cell surface CD11c as a neutrophil aging marker molecule

open access: yesFEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki   +5 more
wiley   +1 more source

CONVERGENCE OF HEALTH EXPENDITURE IN EU 12 AND V4 STATES

open access: yesCopernican Journal of Finance & Accounting, 2017
The subject of this paper is an attempt to assess the level of convergence of government health spending in the European Union countries. The ever-increasing level of life expectancy, demographic changes, including the aging of society in many European ...
Piotr Kułyk, Łukasz Augustowski
doaj   +3 more sources

Sigma Convergence versus Beta Convergence: Evidence from U.S. County-Level Data [PDF]

open access: yes
In this paper we outline (i) why sigma-convergence may not accompany beta-convergence, (ii) discuss evidence of beta-convergence in the U.S., and (iii) use U.S.
Levy, Daniel   +2 more
core   +2 more sources

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

open access: yesFEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Homogenization of a 2D Tidal Dynamics Equation

open access: yesMathematics, 2020
This work deals with the homogenization of two dimensions’ tidal equations. We study the asymptotic behavior of the sequence of the solutions using the sigma-convergence method.
Giuseppe Cardone   +2 more
doaj   +1 more source

Interregional Inequality of Population Incomes: Problems of Methodology and Estimation in the Russian Federation [PDF]

open access: yesSHS Web of Conferences, 2019
Currently, the priority of the Russian Federation socio-economic development is to achieve sustainable economic growth. A significant obstacle to the achievement of this goal is the unevenness and disproportionality in the socio-economic development of ...
Tolmachev M.N.   +3 more
doaj   +1 more source

TESTING SIGMA CONVERGENCE ACROSS EU-28

open access: yesEconomics & Sociology, 2014
ABSTRACT. The main goal of this research is to assess the degree of convergence in European Union- 28 (EU-28) during 2000-2012. After a spatial analysis of macroeconomic indicators using maps and graphs that were built in GeoDa, the sigma convergence was tested.
openaire   +2 more sources

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