Metal‐free carbon catalysts enable the sustainable synthesis of hydrogen peroxide via two‐electron oxygen reduction; however, active site complexity continues to hinder reliable interpretation. This review critiques correlation‐based approaches and highlights the importance of orthogonal experimental designs, standardized catalyst passports ...
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Live-cell imaging of endogenous Egr1 mRNA using an MPBS knock-in mouse model. [PDF]
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Structural proteomics reveals that misfolded nascent proteins expose buried lysines for ubiquitination and rapid proteasomal degradation. [PDF]
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Comparative Metabolomics Reveals the Production of Sulfated Metabolites by Human Gut Bacteria. [PDF]
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Non-canonical amino acid incorporation enables minimally disruptive labeling of stress granule and TDP-43 proteinopathy. [PDF]
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Phenotyping of post-fertilization sperm mitophagy determinants discovered in a mammalian gamete-based cell-free system. [PDF]
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ROOT-ExM: Super-Resolution Imaging of Proteins in <i>Arabidopsis</i> Roots by Expansion Microscopy. [PDF]
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Development and evaluation of a radiobromine-labeled sigma ligand for tumor imaging
Nuclear Medicine and Biology, 2013Sigma receptors are appropriate targets for tumor imaging because they are highly expressed in a variety of human tumors. Previously, we synthesized a vesamicol analog, (+)-2-[4-(4-iodophenyl)piperidino]cyclohexanol ((+)-pIV), with high affinity for sigma receptors, and prepared radioiodinated (+)-pIV.
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The sigma receptor/binding site, found in the brain and periphery, binds haloperidol, (+)-benzomorphans, N-propyl-3-(3-hydroxyphenyl)-piperidine (3-PPP) and certain atypical neuroleptics with high affinity. We have succeeded in ca. 6,000-fold purification of protein(s) from rat and bovine cerebellum which display pharmacology characteristic of the ...
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