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A ¹⁸F-labeled fluorobutyl-substituted spirocyclic piperidine derivative as a selective radioligand for PET Imaging of sigma₁ receptors.

ChemMedChem, 2011
In this study, we synthesized and evaluated a new spirocyclic piperidine derivative 3, containing a 4-fluorobutyl side chain, as a PET radioligand for neuroimaging of σ₁ receptors. In vitro, compound 3 displayed high affinity for σ₁ receptors (K(i) =1.2 nM) as well as high selectivity. [¹⁸F]3 radiosynthesis was performed from the corresponding tosylate
Aurélie, Maisonial +10 more
openaire +1 more source

Sigma Tau revises labelling for levocarnitine ['Carnitor']

Reactions Weekly, 2001
openaire +1 more source

Sigma-1 andSigma-2 sites in rat brain: Comparison of regional, ontogenetic, and subcellular patterns

Synapse, 1994
Tsung-Ping Su, T P Su
exaly

Autoradiographic evidence for the modulation of in vivo sigma receptor labeling by neuropeptide Y and calcitonin gene-related peptide in the mouse brain.

Journal of Pharmacology and Experimental Therapeutics, 1996
J L Junien
exaly

Photoaffinity Labeling of the Sigma-1 Receptor withN-[3-(4-Nitrophenyl)propyl]-N-dodecylamine: Evidence of Receptor Dimers

Biochemistry, 2013
Abdolreza Hajipour +2 more
exaly

In vivo labeling of sigma receptors in mouse brain with [3H]4-phenyl-1-(4-phenylbutyl)piperidine

Synapse, 1995
E D London, U Scheffel
exaly

Pharmacological stimulation of sigma-1 receptor promotes activation of astrocyte via ERK1/2 and GSK3β signaling pathway

Naunyn-Schmiedeberg's Archives of Pharmacology, 2019
Lin Guo, Yun Wang
exaly