Results 241 to 250 of about 770,157 (273)
Some of the next articles are maybe not open access.
Bioorganic & Medicinal Chemistry, 2019
Sigma-1 receptor imaging probes for determining the expression levels are desirable for diagnoses of various diseases and companion diagnoses of therapeutic agents targeting the sigma-1 receptor. In this study, we aimed to develop probes with higher affinity for the sigma-1 receptor.
Kazuma Ogawa +7 more
openaire +2 more sources
Sigma-1 receptor imaging probes for determining the expression levels are desirable for diagnoses of various diseases and companion diagnoses of therapeutic agents targeting the sigma-1 receptor. In this study, we aimed to develop probes with higher affinity for the sigma-1 receptor.
Kazuma Ogawa +7 more
openaire +2 more sources
On \(\Sigma\) and \(\Sigma'\) labelled graphs
Discret. Math., 2009zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +2 more sources
Lu 28-179 labels a σ2-site in rat and human brain
Neuropharmacology, 20021'-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]-1-butyl]spiro[isobenzofuran-1(3H),4'-piperidine] (Lu 28-179) or Siramesine is a sigma-ligand with high specificity for sigma(2)-sites, has been tritiated to directly label these sites in brain. [(3)H]Lu 28-179 bound in a saturable manner to homogenates prepared from rat brain or human cortices with high affinity
Karina Krøyer, Søby +3 more
openaire +2 more sources
In vivo labeling of sigma receptors in mouse brain with [3H]4‐phenyl‐1‐(4‐phenylbutyl)piperidine
Synapse, 1995Abstract4‐Phenyl‐1‐(4‐phenylbutyl)piperidine(4‐PPBP) is a very potent ligand for σ (Sigma) receptors. The present study was undertaken to evaluate [3H]4‐PPBPas a radioligand for in vivo labeling of cerebral σ receptors. After intravenous administration of [3H]4‐PPBP to mice, there is high uptake of radioactivity in the brain.
K, Hashimoto, U, Scheffel, E D, London
openaire +2 more sources
Nuclear Medicine and Biology, 2015
Abstract Introduction Both subtypes of sigma (σ) receptors, σ 1 and σ 2 , are over-expressed in many cancers with σ 2 proposed as a biomarker of tumor proliferation. We are interested in developing a high affinity selective σ 2 radioligand for in vivo monitoring of proliferative status of solid tumors and response to anti-cancer therapies.
Svetlana V. Selivanova +7 more
openaire +2 more sources
Abstract Introduction Both subtypes of sigma (σ) receptors, σ 1 and σ 2 , are over-expressed in many cancers with σ 2 proposed as a biomarker of tumor proliferation. We are interested in developing a high affinity selective σ 2 radioligand for in vivo monitoring of proliferative status of solid tumors and response to anti-cancer therapies.
Svetlana V. Selivanova +7 more
openaire +2 more sources
European Journal of Pharmacology: Molecular Pharmacology, 1994
Rat liver and kidney were investigated for the presence of sigma (sigma) receptor subtypes by radioligand binding with three highly selective sigma probes and by photoaffinity labeling using [3H]azido-di-o-tolylguanidine ([3H]azido-DTG). [3H](+)-Pentazocine, a highly selective sigma 1 probe, bound to sites in liver membranes with Kd = 7.5 nM and Bmax3 =
S B, Hellewell +5 more
openaire +2 more sources
Rat liver and kidney were investigated for the presence of sigma (sigma) receptor subtypes by radioligand binding with three highly selective sigma probes and by photoaffinity labeling using [3H]azido-di-o-tolylguanidine ([3H]azido-DTG). [3H](+)-Pentazocine, a highly selective sigma 1 probe, bound to sites in liver membranes with Kd = 7.5 nM and Bmax3 =
S B, Hellewell +5 more
openaire +2 more sources
Journal of medicinal chemistry, 1991
A series of analogues of the potent and selective sigma receptor ligand 1,3-ditolylguanidine (DTG) were synthesized and demonstrated to have high affinity for the sigma receptor as measured by in vitro [3H]DTG displacement studies using guinea pig brain tissue.
A A, Wilson +5 more
openaire +1 more source
A series of analogues of the potent and selective sigma receptor ligand 1,3-ditolylguanidine (DTG) were synthesized and demonstrated to have high affinity for the sigma receptor as measured by in vitro [3H]DTG displacement studies using guinea pig brain tissue.
A A, Wilson +5 more
openaire +1 more source
Nuclear medicine and biology, 2015
Both subtypes of sigma (σ) receptors, σ₁ and σ₂, are over-expressed in many cancers with σ₂ proposed as a biomarker of tumor proliferation. We are interested in developing a high affinity selective σ₂ radioligand for in vivo monitoring of proliferative status of solid tumors and response to anti-cancer therapies.
Selivanova SV +7 more
openaire +2 more sources
Both subtypes of sigma (σ) receptors, σ₁ and σ₂, are over-expressed in many cancers with σ₂ proposed as a biomarker of tumor proliferation. We are interested in developing a high affinity selective σ₂ radioligand for in vivo monitoring of proliferative status of solid tumors and response to anti-cancer therapies.
Selivanova SV +7 more
openaire +2 more sources