Results 101 to 110 of about 80,497 (310)

Targeting hexokinase 2 to induce breast cancer cell senescence

British Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof, Katarina Cisarova, Sandra Burgstaller, Mia Schwerer, Markus Absenger‐Novak, Philipp J. Jost, Roland Malli, Wolfgang F. Graier, Robert Lukowski   +8 more
wiley   +1 more source

A proposed therapeutic algorithm for colorectal cancer prevention, based on endoscopic polypectomies in patients with multiple colonic polyps [PDF]

, 2018
Introduction. Results from single medical centers having large numbers of patients with multiple colonic polyps that have undergone colonoscopy management are rare. Material and method.
Alexandru, Septimiu, Kutasi, Reka Incze, Moldovan, Cosmin Alec, Ungureanu, Florin D   +3 more
core   +1 more source

Label Noise in Pathological Segmentation Is Overlooked, Leading to Potential Overestimation of Artificial Intelligence

Cancer Science, EarlyView.
This study evaluated how artificial label noise affects cancer pathology segmentation models, demonstrating that boundary‐dependent noise leads to overestimation of performance metrics, while random noise mixtures further harm generalization. Our results highlight the need for standardized noise‐quantification and mitigation methods and for developing ...
Kenji Harada, Yuichiro Nomura, Daisuke Komura, Shumpei Ishikawa, Shingo Sakashita   +4 more
wiley   +1 more source

A retrospective cohort study of the influence of lifestyle factors on survival of patients undergoing surgery for colorectal cancer. [PDF]

, 2017
Aim: Several modifiable and non-modifiable health related behaviours are associated with the incidence of Colorectal Cancer (CRC), but there is little research on their association with survival.
Anderson, Boyle, Campbell, Courneya, Courneya, Dignam, Haggar, Haydon, Holmes, Hubbard, Kuiper, Manceau, Martinez, Meyerhardt, Meyerhardt, Morrison, Oliphant, Shafique, Van Blarigan, Vartiainen, Vrieling, World Cancer Research Fund/American Institute for Cancer Research   +21 more
core   +1 more source

Lipoma of the sigmoid colon

Vojnosanitetski pregled, 2013
Introduction. Lipoma is a benign tumor of adipose tissue, the most common tumor of the human body soft tissues. As such, it can be found almost anywhere in the human body including the gastrointestinal system (incidence below 0.5%), but rarely in the sigmoid colon. Case report. This is a case report on symptomatic polyp of the sigmoid colon,
Đolai Matilda A., Andrejić Bojana M., Ivanov Dejan Đ.   +2 more
openaire   +3 more sources

Dietary anthocyanidin pelargonidin activates G protein‐coupled receptor 35

The FEBS Journal, EarlyView.
Pelargonidin, a red‐fruit‐derived anthocyanidin, was newly identified as a dietary agonist of GPR35, a metabolite‐sensing GPCR implicated in anti‐inflammation. Through screening of dietary compounds, pelargonidin emerged as a potent GPR35 agonist, attenuating inflammation in human intestinal cells.
Fumie Nakashima, Sayako Shimomura, Mayuka Wakabayashi, Wei Qi Loh, Harumi Ando, Haruka Sei, Hiroyuki Hattori, Didik Huswo Utomo, Masaki Kita, Asuka Inoue, Koji Uchida, Takahiro Shibata   +11 more
wiley   +1 more source

Asymptomatic sigmoid diverticulum perforation-induced subcutaneous, mediastinal, and retroperitoneal emphysema: A case report and literature review

Respiratory Medicine Case Reports
Background: Mediastinal and subcutaneous emphysema usually result from spontaneous rupture of the alveolar wall. We present an educational case of subcutaneous, mediastinal, and retroperitoneal emphysema discovered during a routine medical check-up ...
Daichi Setoguchi, Naoki Iwanaga, Kotaro Nema, Tomoya Hagiwara, Kotaro Hayashida, Koki Yamashita, Tatsuro Hirayama, Masataka Yoshida, Kazuaki Takeda, Shotaro Ide, Masato Tashiro, Takahiro Takazono, Masachika Kitajima, Noriho Sakamoto, Koichi Izumikawa, Katsunori Yanagihara, Keiji Inoue, Hiroshi Mukae   +17 more
doaj   +1 more source

Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition [PDF]

, 2016
EZH2 inhibitors have gained great interest for their use as anti-cancer therapeutics. However, most research has focused on EZH2 mutant cancers and recently adverse effects of EZH2 inactivation have come to light.
Bounova, Gergana, Cornelissen-Steijger, Paulien, de Vries, Nienke, Koppens, Martijn A.J., Sansom, Owen J., van Lohuizen, Maarten, Wessels, Lodewyk F.A.   +6 more
core   +1 more source

Survival benefit of high ligation of the inferior mesenteric artery in sigmoid colon or rectal cancer surgery (Br J Surg 2006; 93: 609–615) [PDF]

, 2006
Durgatosh Pandey
openalex   +1 more source

Brain tissue classification in hyperspectral images using multistage diffusion features and transformer

Journal of Microscopy, EarlyView.
Abstract Brain surgery is a widely practised and effective treatment for brain tumours, but accurately identifying and classifying tumour boundaries is crucial to maximise resection and avoid neurological complications. This precision in classification is essential for guiding surgical decisions and subsequent treatment planning.
Neetu Sigger, Tuan T. Nguyen, Gianluca Tozzi   +2 more
wiley   +1 more source