Results 81 to 90 of about 80,497 (310)

Reshaping study design for faster extrapolation‐based drug approval in pediatric inflammatory bowel diseases: An ESPGHAN–NASPGHAN position paper

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Children with inflammatory bowel diseases (IBD) have limited access to the available advanced therapies, given the lengthy gap between adult and pediatric approval. We aimed to review key hurdles for pediatric trials and recommend practical solutions.
Dan Turner, Amit Assa, Mikkel Malham, Shira Yuval Bar‐Asher, Carla Rayan, Jeffrey S. Hyams, Holm H. Uhlig, Brad Pasternak, David C. Wilson, Hilary K. Michel, Lissy de Ridder, Eric Zuckerman, Marina Aloi, Peter Szitanyi, Marla C. Dubinsky, Anne M. Griffiths, Roberto Saldana, Javier Martín‐de‐Carpi, Eytan Wine, Richard K. Russell, Jeremy Adler, Joseph Picoraro   +21 more
wiley   +1 more source

Synchronous volvulus of the transverse and sigmoid colon: a rare case of large bowel obstruction

The Pan African Medical Journal, 2021
Colonic volvulus usually occurs as a single event that can affect various parts of the colon. The usual sites affected being the sigmoid colon (75%) and the caecum (22%). The phenomenon of multiple sites simultaneously undergoing volvulus is an extremely
Abderrahim Samlali, Said Boussaidane, Asma Hamri, Youssef Narjis, Ridouan Benelkhaiat Benomar   +4 more
doaj   +1 more source

Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer : diagnostic and therapeutic potential [PDF]

, 2015
Caspases are a group of proteolytic enzymes involved in the co-ordination of cellular processes, including cellular homeostasis, inflammation and apoptosis.
Caiazza, F, Creagh, EM, Doherty, GA, Fay, J, Flood, B, Heetun, Z, Kay, E, Laukens, Debby, Mills, KHG, O'Grady, A, Oficjalska, K, Ryan, EJ, Sheahan, K   +12 more
core   +2 more sources

P754 Beyond Paneth cell metaplasia: Small intestinal metaplasia of the sigmoid colon in patients with Inflammatory Bowel Disease [PDF]

, 2023
Anne Koehne de González, Armando Del Portillo   +1 more
openalex   +1 more source

Characterization of pediatric eosinophilic gastrointestinal disorders beyond eosinophilic esophagitis in a nationwide cohort

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Nonesophageal eosinophilic gastrointestinal disorders (non‐EoE EGIDs) are rare, underrecognized inflammatory diseases of the gastrointestinal (GI) tract, especially in children. Their clinical heterogeneity and lack of specific biomarkers contribute to diagnostic delays and therapeutic challenges.
Sara Renzo, Luca Scarallo, Selene Del Vespa, Giulia Angelino, Matteo Bramuzzo, Enrico Felici, Flavio Labriola, Francesca Laganà, Lorenzo Norsa, Salvatore Oliva, Marisa Piccirillo, Elena Pozzi, Francesca Rea, Giusy Russo, Francesco Valitutti, Giovanna Zuin, Paolo Lionetti   +16 more
wiley   +1 more source

Dolichocolon is common in pediatric gastroenterology patients with constipation and associated complaints

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Dolichocolon (DC), classified under ICD‐10 code Q43.8 (“Other specified congenital malformations of intestine”), refers to an elongated or redundant large intestine. Recent studies in adults indicate a role for dolichocolon in constipation and disorders of gut‐brain interaction.
David Simon, Donovan Berens, Raul Zambrana Valenzuela, Arvind Mohan, Partha Chakraborty, Timot Kellermayer, Eric H. Chiou, Craig L. Jensen, Ricardo A. Arbizu, Marla B. K. Sammer, Richard Kellermayer   +10 more
wiley   +1 more source

Anatomical Region of the Colon as an Influencing Factor for Ulcerative Colitis Development

Central Asian Journal of Medical Sciences, 2016
Objectives: To determine if the anatomical location and extent of ulcerative inflammation influences the primary development of ulcerative colitis by defining the primary starting locations of ulcerative inflammation processes and determining the ...
Enkhbaatar Tseden, Adilzaya Damdinsuren, Davaadorj Duger   +2 more
doaj   +1 more source

Internal hernia of the stomach associated with colostomy after laparoscopic surgery for rectal cancer: a case report

Surgical Case Reports, 2020
Background Colostomy via the intraperitoneal route is often performed during laparoscopic Hartmann’s operation or abdominoperineal resection. Internal hernia of the small intestine often occurs after colostomy.
Hiroki Hashida, Ryosuke Kita, Masato Kondo, Ryosuke Mizuno, Hiroyuki Kobayashi, Satoshi Kaihara   +5 more
doaj   +1 more source

Afatinib use in recurrent epithelial ovarian carcinoma. [PDF]

, 2019
•Genomic tumor testing is an important tool in guiding treatment for gynecologic malignancies.•Targetable mutations may lead to new therapies in gynecologic cancer treatment.•Her2/neu mutations in serous ovarian carcinomas can be targeted with ERBB2 ...
Alvarez, Edwin A, Hanft, Wyatt J, Kennedy, Vanessa A, Shepherd-Littlejohn, Amanda L   +3 more
core   +1 more source

Clinical, manometric, genetic, and histologic associations in pediatric intestinal pseudo‐obstruction: A case series

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Pediatric intestinal pseudo‐obstruction (PIPO) is a severe bowel motility disorder characterized by impaired propulsion of gastrointestinal contents without mechanical obstruction. PIPO encompasses congenital and acquired disorders, including neuropathies, myopathies, and mesenchymopathies.
Sharon Wolfson, Myra Butrviengpunt, Naomi Tjaden, Alain J. Benitez, Archana S. Kota, Jennifer Webster, Prasanna Kapavarapu, Hayat Mousa, Robert O. Heuckeroth   +8 more
wiley   +1 more source