Results 171 to 180 of about 28,227 (259)

Multiple primary malignant neoplasms and long-term survival: A case report. [PDF]

Oncol Lett
Xie B, Huang K, Zhu S.
europepmc   +1 more source

Integrated Population Pharmacokinetic, Pharmacodynamic, and Safety Analyses to Inform Dosage Selection in the Clinical Development of the ATR Inhibitor Tuvusertib

Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 618-628, March 2026.
We present model‐informed selection of the recommended dose for expansion (RDE) of investigational oral ATR inhibitor tuvusertib, by integrating clinical pharmacokinetics (PK), pharmacodynamics (PD), and safety data from DDRiver Solid Tumors 301 trial Part A1 (NCT04170153).
Jatinder Kaur Mukker, Paul Matthias Diderichsen, Farina Hellmann, Timothy A. Yap, Ruth Plummer, Anthony W. Tolcher, Johann S. de Bono, Ioannis Gounaris, Zoltan Szucs, Astrid Zimmermann, Irina Kareva, Jayaprakasam Bolleddula, Annick Seithel‐Keuth, Giuseppe Locatelli, Marta Enderlin, Christine Hicking, Anup Zutshi, Wei Gao, Rainer Strotmann, Lisa Benincosa, Karthik Venkatakrishnan   +20 more
wiley   +1 more source

Invasive Bladder Cancer With Peritoneal Invasion and Rectal Involvement Causing Rectal, Bilateral Ureteral, and Common Bile Duct Obstruction Without a Retroperitoneal Mass: A Case Report

IJU Case Reports, Volume 9, Issue 2, March 2026.
ABSTRACT Introduction Bladder cancer (BC) is rarely associated with common bile duct (CBD) obstruction. We report a case of BC with peritoneal invasion and rectal involvement complicated by bilateral ureteral and biliary obstruction. Case Presentation A 77‐year‐old man presented with abdominal pain.
Kazuto Imai, Norihiko Masuda, Tatsuya Hazama, Toshihide Hosomi, Keita Hanada, Takakazu Matsushita, Toshiya Akao   +6 more
wiley   +1 more source

Reshaping study design for faster extrapolation‐based drug approval in pediatric inflammatory bowel diseases: An ESPGHAN–NASPGHAN position paper

Journal of Pediatric Gastroenterology and Nutrition, Volume 82, Issue 3, Page 867-894, March 2026.
Abstract Children with inflammatory bowel diseases (IBD) have limited access to the available advanced therapies, given the lengthy gap between adult and pediatric approval. We aimed to review key hurdles for pediatric trials and recommend practical solutions.
Dan Turner, Amit Assa, Mikkel Malham, Shira Yuval Bar‐Asher, Carla Rayan, Jeffrey S. Hyams, Holm H. Uhlig, Brad Pasternak, David C. Wilson, Hilary K. Michel, Lissy de Ridder, Eric Zuckerman, Marina Aloi, Peter Szitanyi, Marla C. Dubinsky, Anne M. Griffiths, Roberto Saldana, Javier Martín‐de‐Carpi, Eytan Wine, Richard K. Russell, Jeremy Adler, Joseph Picoraro   +21 more
wiley   +1 more source

Aberrant TTF-1 expression in metastatic colorectal adenocarcinoma mimicking primary lung cancer: a case report and review of diagnostic pitfalls. [PDF]

Diagn Pathol
Tran NT, Van Thai N, Khuyen NT, Le LT, Khoa LTA.   +4 more
europepmc   +1 more source

Cerebral Venous Outflow Insufficiency: A Study on Symptoms and Venous Stenosis Classification

MedComm, Volume 7, Issue 3, March 2026.
Cerebral venous outflow insufficiency (CVOI) predominantly consists of 10 cerebral venous congestion symptoms. Based on the traditional classification according to imaging features, this study classified CVOI into intracranial (CV), extracranial (JV), and tandem (CJV) types, which better reflect the imaging features and pathological types of patients ...
Hui Li, Xiaojiao Guan, Lu Liu, Chunxiao Lu, Weiyue Zhang, Yifan Zhou, Huimin Jiang, Chenxia Zhou, Jian Dong, Xunming Ji, Chen Zhou   +10 more
wiley   +1 more source

Recent Treatment Options for Primary Colonic Leiomyosarcoma: A Case Report and a Review of the Literature. [PDF]

Surg Case Rep
Dejima A, Momiyama M, Nakajima K, Tsuru M, Sakuma J, Nagao A, Hashimoto H, Uchino K, Kawai K, Satou S.   +9 more
europepmc   +1 more source

A prescription‐free, radiobiology‐based framework for automated VMAT planning: A feasibility study in primary prostate cancer radiotherapy

Medical Physics, Volume 53, Issue 3, March 2026.
Abstract Background Current VMAT planning workflows for prostate cancer primarily depend on conventional dose–volume criteria specified at discrete dose or volume points. These point‐based objectives, however, do not necessarily lead to globally optimal, patient‐specific treatment plans.
Dejan Kuhn, Simon K. B. Spohn, Constantinos Zamboglou, Anca‐Ligia Grosu, Dimos Baltas, Ilias Sachpazidis   +5 more
wiley   +1 more source

Atypical Cervical Myelopathy with Medullary Involvement from Intracranial Dural Arteriovenous Fistula: The Steroid Trap. [PDF]

Ann Indian Acad Neurol
Agarwal U, Gupta V, Singla RS, Parthasarathy R.   +3 more
europepmc   +1 more source