Results 181 to 190 of about 28,227 (259)

A voxel‐wise uncertainty‐guided framework for glioma segmentation using spherical projection‐based U‐Net and localized refinement

open access: yesMedical Physics, Volume 53, Issue 3, March 2026.
Abstract Background Accurate segmentation of glioma subregions from multi‐parametric MRI (MP‐MRI) is critical for clinical management but remains challenging due to tumor heterogeneity and ambiguous tissue boundaries. Purpose This study proposes an uncertainty‐guided hybrid segmentation framework that integrates spherical projection‐based 2D modeling ...
Zhenyu Yang   +5 more
wiley   +1 more source

¹H NMR Chemical Shifts and J‐Coupling Constants Dependence on Temperature and pH: Implications for the Quantification of Relevant Metabolites

open access: yesNMR in Biomedicine, Volume 39, Issue 3, March 2026.
1H MRS, in combination with quantification methods using model functions based on prior knowledge of chemical shifts and coupling constants, allows the determination of characteristic metabolic processes in healthy and diseased tissue. Using the functional relationships δpHT$$ \delta \left( pH,T\right) $$ and JpHT$$ J\left( pH,T\right) $$ enables this ...
Felizitas C. Wermter   +2 more
wiley   +1 more source

Post‐translational regulation of human D‐3‐phosphoglycerate dehydrogenase in Alzheimer's disease

open access: yesProtein Science, Volume 35, Issue 3, March 2026.
Abstract Emerging evidence suggests that sex‐specific differences in L‐serine (L‐Ser) metabolism play a key role in Alzheimer's disease (AD). While disruptions in amino acid balance are well known, recent findings point to a dimorphic regulation of the serine biosynthetic pathway.
Elena Zerbini   +5 more
wiley   +1 more source

Population PK/PD Modeling for Evaluation of Intertwining Effects of Drug and Disease on Thrombocytopenia in Acute Leukemias

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 3, March 2026.
ABSTRACT In hematological malignancies, thrombocytopenia is a frequent feature of the disease. Anti‐leukemic therapies are known to impact thrombocytopenia, which is commonly selected as a dose‐limiting toxicity in early clinical trials. However, given the concurrent myelosuppressive effects of the drug and the underlying leukemia, it can be difficult ...
Tomás Sou   +2 more
wiley   +1 more source

Integrated Assessment of Intestinal Barrier Function and Microscopic Inflammation Using Confocal Laser Endomicroscopy for Relapse Prediction in Ulcerative Colitis

open access: yesUnited European Gastroenterology Journal, Volume 14, Issue 2, March 2026.
ABSTRACT Background Although the current strategy in ulcerative colitis (UC) focuses on achieving endoscopic healing to improve long‐term outcomes, patients with persistent microscopic inflammation or intestinal barrier dysfunction remain at increased risk of relapse.
Horia Minea   +14 more
wiley   +1 more source

Urachal adenocarcinoma: a case report and literature review. [PDF]

open access: yesJ Surg Case Rep
Kostara K   +4 more
europepmc   +1 more source

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