Results 101 to 110 of about 10,457,446 (242)

Existence of at least four solutions for Schrodinger equations with magnetic potential involving and sign-changing weight function

Electronic Journal of Differential Equations, 2023
Francisco Odair de Paiva, Sandra Machado de Souza Lima, Olimpio H. Miyagaki   +2 more
doaj  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Scenic 89 road sign

, 1965
Scenic 89 tourism road sign photographed along Highway 89 in Kane County as part of a project by the State Department of Highways to document Utah highways signs.This series contains outdoor advertising sign inventories conducted by the Department of ...
Road Commission. Department of Highways
core   +1 more source

Multiple solutions for Schrodinger-Poisson systems with sign-changing potential and critical nonlinearity

Electronic Journal of Differential Equations, 2016
In this article, we study the Schr\"odinger-Poisson system $$\displaylines{ -\Delta u+V(x)u+k(x)\phi(x)u=h_1(x)|u|^{4}u+\mu h_{2}(x)u+h_3(x), \quad\text{in } \mathbb{R}^3, \cr -\Delta \phi(x)=k(x)u^2 , \quad\text{in } \mathbb{R}^3, }$$ where $h_1(x)
Liuyang Shao, Haibo Chen
doaj  

Sign-Changing Solutions for the Fractional Choquard Equation

Axioms
We study a class of fractional Choquard equation with continuous potential. This equation is a doubly nonlocal problem which has two nonlocal term: fractional Laplacian operator and convolution term. Using variaotional metheod and some estimates, we give
Ying-Xin Cui, Qiaoyan Li
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Existence of bound state solutions for degenerate singular perturbation problems with sign-changing potentials

Electronic Journal of Differential Equations, 2012
In this article, we study the degenerate singular perturbation problems $$displaylines{ -varepsilon^2hbox{div}(|x|^{-2a}abla u)+|x|^{-2(a+1)}V(x)u = |x|^{-b2^*(a,b)}g(x,u),cr -hbox{div}(|x|^{-2a}abla u)+ lambda |x|^{-2(a+1)}V(x)u = |x|^{-b2^*(a,b)}g(
Maria J. Alves, Ronaldo B. Assuncao, Paulo C. Carriao, Olimpio H. Miyagaki   +3 more
doaj  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source