Results 81 to 90 of about 10,457,446 (242)
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Solutions for a Logarithmic Fractional Schrödinger-Poisson System with Asymptotic Potential
Fractal and FractionalIn this paper, we consider a logarithmic fractional Schrödinger-Poisson system where the potential is a sign-changing function. When the potential is coercive, we get the existence of infinitely many solutions for the system.
Lifeng Guo, Yuan Li, Sihua Liang
doaj +1 more source
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2019 In this paper we are concerned with the study of the spectrum for a class of eigenvalue problems driven by two non-homogeneous differential operators with different variable growth and an indefinite potential in the following ...
Uţă Vasile-Florin
doaj +1 more source
Two solutions for nonhomogeneous Klein-Gordon-Maxwell system with sign-changing potential
Electronic Journal of Differential Equations, 2018 In this article, we study the nonhomogeneous Klein-Gordon-Maxwell system $$\displaylines{ - \Delta u +\lambda V(x)u-K(x)(2\omega+\phi)\phi u =f(x,u)+h(x), \quad x\in \mathbb{R}^3,\cr \Delta \phi =K(x)(\omega+\phi)u^2, \quad x\in \mathbb{R}^3, }$$
Lixia Wang, Shangjie Chen
doaj
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source