Results 61 to 70 of about 10,457,446 (242)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Combining data-driven MT systems for improved sign language translation [PDF]

, 2007
In this paper, we investigate the feasibility of combining two data-driven machine translation (MT) systems for the translation of sign languages (SLs).
Morrissey, Sara, Stein, Daniel, Way, Andy, Bungeroth, Jan, Ney, Hermann   +4 more
core   +3 more sources

Infinitely many solutions for elliptic boundary value problems with sign-changing potential

Electronic Journal of Differential Equations, 2014
In this article, we study the elliptic boundary value problem $$\displaylines{ -\Delta u+a(x)u=g(x, u) \quad \text{in } \Omega,\cr u = 0\quad \text{on } \partial \Omega, }$$ where $ \Omega\subset \mathbb{R}^N$ $(N\geq3)$ is a bounded domain with
Wen Zhang, Xianhua Tang, Jian Zhang
doaj  

Guideline sign code, a format for the municipal regulation of on-premise signs

, 1981
Special funding to assist in the production and distribution of this publication was provided by the World Sign ...
National Electric Sign Association
core  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

The Interpreters' Newsletter 19, Sign Language Interpreting

, 2014
This issue of The Interpreters’ Newsletter aims to address a number of topics of interest in this growing area of Interpreting Studies presented in the form of discussion on prevailing situations, personal impressions on the profession (e.g.
Schaumberger Elke, Freelance Sign Language interpreter, Napier Jemina, Heriot Watt University, de Wit Maya, Freelance Sign Language interpreter, Swabey Laurie, S. t. Catherine University, Sluis Irma, Freelance Sign Language interpreter, Wang Jihong, Macquarie University, Alley Erica, S. t. Catherine University, Kellett, CYNTHIA JANE MARY, Nicodemus Brenda, Gallaudet University, Kellett C.J, Shaw Sherry, University of North Florida, Taylor Marty M., Interpreting Consolidated, Brück Patricia, Freelance Sign Language interpreter   +12 more
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Analysis of the Normalized Sign-Sign LMS Algorithm

, 2021
This work repots results of the convergence analysis of the normalized sign-sign least mean square (NSSLMS) algorithm when the input is real-valued data.
Zerguine, A., Ulla Faiz, M.
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source