Results 31 to 40 of about 10,457,446 (242)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa   +7 more
wiley   +1 more source

Multiple solutions for a fractional p-Laplacian equation with sign-changing potential

open access: yesElectronic Journal of Differential Equations, 2016
We use a variant of the fountain Theorem to prove the existence of infinitely many weak solutions for the fractional p-Laplace equation $$\displaylines{ (-\Delta)_p^s u + V(x) |u|^{p-2}u = f(x, u) \quad \text{in } \mathbb{R}^N, }$$ where $s\in (0,1)
Vincenzo Ambrosio
doaj  

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin   +2 more
wiley   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Existence of solutions for the fractional Kirchhoff equations with sign-changing potential

open access: yesBoundary Value Problems, 2018
In this paper, the authors investigate the following fractional Kirchhoff boundary value problem: {(a+b∫0T(0Dtαu)2dt)tDTα(0Dtαu)+λV(t)u=f(t,u),t∈[0,T],u(0)=u(1)=0, $$ \textstyle\begin{cases} ( {a+b\int_{0}^{T} {({ }_{0}D_{t}^{\alpha }u)^{2}\,dt} } ){ }_ ...
Guoqing Chai, Weiming Liu
doaj   +1 more source

Multiplicity results for sublinear elliptic equations with sign-changing potential and general nonlinearity

open access: yesBoundary Value Problems, 2020
In this paper, we study the following elliptic boundary value problem: { − Δ u + V ( x ) u = f ( x , u ) , x ∈ Ω , u = 0 , x ∈ ∂ Ω , $$ \textstyle\begin{cases} -\Delta u+V(x)u=f(x, u),\quad x\in \Omega , \\ u=0, \quad x \in \partial \Omega , \end{cases} $
Wei He, Qingfang Wu
doaj   +1 more source

Multiple solutions for semilinear elliptic equations with sign-changing potential and nonlinearity

open access: yesElectronic Journal of Differential Equations, 2013
In this article, we study the multiplicity of solutions for the semilinear elliptic equation $$\displaylines{ -\Delta u+a(x)u=f(x, u), \quad x\in \Omega,\cr u=0, \quad x \in \partial\Omega, }$$ where $ \Omega\subset \mathbb{R}^N$ $(N ...
Dongdong Qin, Xianhua Tang, Jiang Zhang
doaj  

PERIODIC SOLUTIONS OF SINGULAR DIFFERENTIAL EQUATIONS WITH SIGN-CHANGING POTENTIAL

open access: yes, 2010
In this paper we study the existence of positive periodic solutions to second-order singular differential equations with the sign-changing potential. Both the repulsive case and the attractive case are studied.
JIFENG CHU, ZIHENG ZHANG
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Critical quasilinear Schrodinger equation with sign-changing potential

open access: yesElectronic Journal of Differential Equations, 2016
We study the existence of nontrivial solutions for a class of quasilinear Schrodinger equations in R^N with critical nonlinearity, where the potential is allowed to change signs.
Li-Li Wang, Zhi-Qing Han
doaj  

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