Results 81 to 90 of about 5,473,308 (246)

Sign-changing solutions of p-Laplacian equation with a sub-linear nonlinearity at infinity

Electronic Journal of Differential Equations, 2013
In this article we obtain some existence and multiplicity results for sign-changing solutions of a $p$-Laplacian equation. We use the method of lower and upper solutions and Leray-Schauder degree theory.
Xian Xu, Bin Xu
doaj  

Existence of Nontrivial Solutions for Some Second-Order Multipoint Boundary Value Problems

Journal of Function Spaces, 2018
By using fixed point theorems with lattice structure, the existence of negative solution and sign-changing solution for some second-order multipoint boundary value problems is obtained.
Hongyu Li, Junting Zhang
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Sign-changing solution for critical Schrödinger–Poisson system with concave perturbation

Electronic Journal of Qualitative Theory of Differential Equations
In this paper, we consider the following Schrödinger–Poisson system with critical-concave nonlinearity: \begin{equation*} \begin{cases} \displaystyle -\Delta u+l(x)\phi u =|u|^4u+\mu h(x)|u|^{q-2}u &\mbox{in}\ \mathbb{R}^3, \\ \displaystyle -
Yu-Ru Li, Yong-Yong Li
doaj   +1 more source

Multiple positive solutions for nonlocal problems involving a sign-changing potential

Electronic Journal of Differential Equations, 2017
In this article we show the existence and multiplicity of positive solutions for the nonlocal problem with a sign-changing weight function, $$\displaylines{ -(a-b\int_{\Omega}|\nabla u|^2dx)\Delta u= f_\lambda(x)|u|^{q-2}u, \quad\text{in }\Omega ...
Chun-Yu Lei, Jia-Feng Suo
doaj  

Multiplicity of Positive Solutions for a Singular Tempered Fractional Initial-Boundary Value Problem with Changing-Sign Perturbation Term

Fractal and Fractional
In this paper, we focus on the multiplicity of positive solutions for a singular tempered fractional initial-boundary value problem with a p-Laplacian operator and a changing-sign perturbation term.
Xinguang Zhang, Peng Chen, Lishuang Li, Yonghong Wu   +3 more
doaj   +1 more source

Infinitely Many Sign-Changing Solutions for Some Nonlinear Fourth-Order Beam Equations

Abstract and Applied Analysis, 2013
Several new existence theorems on positive, negative, and sign-changing solutions for the following fourth-order beam equation are obtained: u(4)=f(t,u(t)),   t∈[0,1];  u(0)=u(1)=u′′(0)=u′′(1)=0, where f∈C([0,1]×ℝ1,ℝ1).
Ying Wu, Guodong Han
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source