Results 61 to 70 of about 44,643 (219)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A sign-changing solution for a superlinear Dirichlet problem, II

Electronic Journal of Differential Equations, 2003
In previous work by Castro, Cossio, and Neuberger cite{ccn}, it was shown that a superlinear Dirichlet problem has at least three nontrivial solutions when the derivative of the nonlinearity at zero is less than the first eigenvalue of $-Delta$ with zero
Alfonso Castro, Pavel Drabek, John M. Neuberger   +2 more
doaj  

Multiplicity of Positive Solutions for a Singular Tempered Fractional Initial-Boundary Value Problem with Changing-Sign Perturbation Term

Fractal and Fractional
In this paper, we focus on the multiplicity of positive solutions for a singular tempered fractional initial-boundary value problem with a p-Laplacian operator and a changing-sign perturbation term.
Xinguang Zhang, Peng Chen, Lishuang Li, Yonghong Wu   +3 more
doaj   +1 more source

Infinitely Many Sign-Changing Solutions for Some Nonlinear Fourth-Order Beam Equations

Abstract and Applied Analysis, 2013
Several new existence theorems on positive, negative, and sign-changing solutions for the following fourth-order beam equation are obtained: u(4)=f(t,u(t)),   t∈[0,1];  u(0)=u(1)=u′′(0)=u′′(1)=0, where f∈C([0,1]×ℝ1,ℝ1).
Ying Wu, Guodong Han
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Multiple positive solutions for nonlocal problems involving a sign-changing potential

Electronic Journal of Differential Equations, 2017
In this article we show the existence and multiplicity of positive solutions for the nonlocal problem with a sign-changing weight function, $$\displaylines{ -(a-b\int_{\Omega}|\nabla u|^2dx)\Delta u= f_\lambda(x)|u|^{q-2}u, \quad\text{in }\Omega ...
Chun-Yu Lei, Jia-Feng Suo
doaj  

Existence and convergence of sign-changing solutions for Kirchhoff-type $p$-Laplacian problems involving critical exponent in $\mathbb{R}^N$

Electronic Journal of Qualitative Theory of Differential Equations
We investigate the existence of sign-changing solutions for Kirchhoff-type problems with $p$-Laplacian involving critical exponent: \begin{equation*} -\left(1+b \vert \nabla v \vert_p^p\right)\Delta_p v+a(x)\vert v\vert^{p-2}v=\vert v\vert^{p^*-2}v ...
Youssouf Chahma, Yang Han
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Least energy sign-changing solutions for nonlinear problems involving fractional Laplacian

Electronic Journal of Differential Equations, 2016
In this article, we study the existence of least energy sign-changing solutions for nonlinear problems involving fractional Laplacian. By introducing some new ideas and combining constraint variational method with the quantitative deformation lemma ...
Zu Gao, Xianhua Tang, Wen Zhang
doaj