Results 51 to 60 of about 44,643 (219)

Existence of Nontrivial Solutions for Some Second-Order Multipoint Boundary Value Problems

Journal of Function Spaces, 2018
By using fixed point theorems with lattice structure, the existence of negative solution and sign-changing solution for some second-order multipoint boundary value problems is obtained.
Hongyu Li, Junting Zhang
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

On a Kirchhoff Equation in Bounded Domains

Advanced Nonlinear Studies, 2018
In this paper, we consider the following Kirchhoff equation:
Huang Yisheng, Wu Yuanze
doaj   +1 more source

Mountain pass and linking type sign-changing solutions for nonlinear problems involving the fractional Laplacian

Boundary Value Problems, 2017
In this paper we study the existence of sign-changing solutions for nonlinear problems involving the fractional Laplacian 0.1 { ( − Δ ) s u − λ u = f ( x , u ) , x ∈ Ω , u = 0 , x ∈ R n ∖ Ω , $$ \left \{ \textstyle\begin{array}{l@{\quad}l} (-\Delta)^{s}u-
Huxiao Luo, Xianhua Tang, Shengjun Li
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Sign-changing solution for critical Schrödinger–Poisson system with concave perturbation

Electronic Journal of Qualitative Theory of Differential Equations
In this paper, we consider the following Schrödinger–Poisson system with critical-concave nonlinearity: \begin{equation*} \begin{cases} \displaystyle -\Delta u+l(x)\phi u =|u|^4u+\mu h(x)|u|^{q-2}u &\mbox{in}\ \mathbb{R}^3, \\ \displaystyle -
Yu-Ru Li, Yong-Yong Li
doaj   +1 more source

Nonradial solutions for semilinear Schrödinger equations with sign-changing potential

Electronic Journal of Qualitative Theory of Differential Equations, 2015
In this paper, we investigate the existence of infinite nonradial solutions for the Schrödinger equations \begin{equation*} \begin{cases} -\triangle u+b(|x|)u=f(|x|, u), &\quad x\in {\mathbb{R}}^{N},\\ u\in H^{1}({\mathbb{R}}^{N}), \end ...
Dingyang Lv, Xuxin Yang
doaj   +1 more source