Interchromosomal linkage disequilibrium analysis reveals strong indications of sign epistasis in wheat breeding families [PDF]
G3: Genes, Genomes, GeneticsAbstract Additive gene action is assumed to underly quantitative traits, but the eventual poor performance of elite wheat lines as parents suggests that epistasis could be the underlying genetic architecture. Sign epistasis is characterized by alleles having either a beneficial or detrimental effect depending on the genetic background,
Geoffrey P Morris +2 more
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The Valley-of-Death: Reciprocal sign epistasis constrains adaptive trajectories in a constant, nutrient limiting environment [PDF]
Genomics, 2014 The fitness landscape is a powerful metaphor for describing the relationship between genotype and phenotype for a population under selection. However, empirical data as to the topography of fitness landscapes are limited, owing to difficulties in measuring fitness for large numbers of genotypes under any condition.
Daniel J Kvitek +2 more
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PERSPECTIVE: SIGN EPISTASIS AND GENETIC COSTRAINT ON EVOLUTIONARY TRAJECTORIES [PDF]
Evolution; International Journal of Organic Evolution, 2005 Epistasis for fitness means that the selective effect of a mutation is conditional on the genetic background in which it appears. Although epistasis is widely observed in nature, our understanding of its consequences for evolution by natural selection remains incomplete.
Daniel M Weinreich +2 more
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Reciprocal sign epistasis is a necessary condition for multi-peaked fitness landscapes [PDF]
Journal of Theoretical Biology, 2011 Having multiple peaks within fitness landscapes critically affects the course of evolution, but whether their presence imposes specific requirements at the level of genetic interactions remains unestablished. Here we show that to exhibit multiple fitness peaks, a biological system must contain reciprocal sign epistatic interactions, which are defined ...
Frank J Poelwijk, Sander J Tans
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Sign Epistasis Can be Absent in Multi-peaked Landscapes With Neutral Mutations [PDF]
Genome Biology and EvolutionDmitry N Ivankov
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Occurrences of reciprocal sign epistasis in single- and multi-peaked theoretical fitness landscapes
Journal of Physics A: Mathematical and Theoretical, 2022Abstract Fitness landscapes help model the theory of adaption. We consider genetic fitness landscapes abstractly as acyclic orientations of Boolean lattices under the assumptions laid out by Crona et al .
Manda Riehl +3 more
openaire +3 more sources
A SHIFT FROM MAGNITUDE TO SIGN EPISTASIS DURING ADAPTIVE EVOLUTION OF A BACTERIAL SOCIAL TRAIT [PDF]
Evolution; International Journal of Organic Evolution, 2014 Although the importance of epistasis in evolution has long been recognized, remarkably little is known about the processes by which epistatic interactions evolve in real time in specific biological systems. Here, we have characterized how the epistatic fitness relationship between a social gene and an adapting genome changes radically over a short ...
Helena Mendes-Soares +2 more
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Since the dawn of agriculture, humans have applied artificial selection on traits of interest, regardless of their genetic architecture. Yet, still today, most models used to study and streamline this process overlook genetic interactions. In this study, we determined the conditions in which a target genotype can be fixed when truncation selection is ...
Constance Vagne
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The Rank Ordering of Genotypic Fitness Values Predicts Genetic Constraint on Natural Selection on Landscapes Lacking Sign Epistasis [PDF]
Genetics, 2005 Abstract Sewall Wright's genotypic fitness landscape makes explicit one mechanism by which epistasis for fitness can constrain evolution by natural selection. Wright distinguished between landscapes possessing multiple fitness peaks and those with only a single peak and emphasized that the former class imposes substantially greater ...
Daniel M Weinreich
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