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Lack of Evidence for Sign Epistasis Between Beneficial Mutations in an RNA Bacteriophage
Journal of Molecular Evolution, 2010In previous work (Betancourt, Genetics 181:1535, 2009), I propagated three large laboratory populations of an RNA phage (MS2) as they adapted to a controlled laboratory environment. These populations were large enough so that evolution might be expected to be mostly repeatable, but they nevertheless fixed different suites of mutations over the course ...
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Evolution; international journal of organic evolution, 2014
Adaptation of one set of traits is often accompanied by attenuation of traits important in other selective environments, leading to fitness trade-offs. The mechanisms that either promote or prevent the emergence of trade-offs remain largely unknown, and are difficult to discern in most systems.
Sean Michael, Carroll +2 more
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Adaptation of one set of traits is often accompanied by attenuation of traits important in other selective environments, leading to fitness trade-offs. The mechanisms that either promote or prevent the emergence of trade-offs remain largely unknown, and are difficult to discern in most systems.
Sean Michael, Carroll +2 more
openaire +1 more source
2016
Adaptation of one set of traits is often accompanied by attenuation of traits important in other selective environments, leading to fitness trade-offs. The mechanisms that either promote or prevent the emergence of trade-offs remain largely unknown, and are difficult to discern in most systems.
Marx, CJ, Lee, MC, Carroll, SM
openaire +2 more sources
Adaptation of one set of traits is often accompanied by attenuation of traits important in other selective environments, leading to fitness trade-offs. The mechanisms that either promote or prevent the emergence of trade-offs remain largely unknown, and are difficult to discern in most systems.
Marx, CJ, Lee, MC, Carroll, SM
openaire +2 more sources
PERSPECTIVE:SIGN EPISTASIS AND GENETIC CONSTRAINT ON EVOLUTIONARY TRAJECTORIES
Evolution; International Journal of Organic Evolution, 2005Daniel M Weinreich +2 more
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Epistasis and quantitative traits: using model organisms to study gene–gene interactions
Nature Reviews Genetics, 2013Trudy F C Mackay
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Epistasis between mutations is host-dependent for an RNA virus
Biology Letters, 2013Jasna Lalić, Santiago F Elena
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