Results 21 to 30 of about 7,799 (146)
Interaction of Wnt pathway related variants with type 2 diabetes in a Chinese Han population [PDF]
PeerJ, 2015 Aims. Epistasis from gene set based on the function-related genes may confer to the susceptibility of type 2 diabetes (T2D). The Wnt pathway has been reported to play an important role in the pathogenesis of T2D.
Jian-Bo Zhou +3 more
doaj +2 more sources
High-Resolution Quantitative Trait Locus Mapping Reveals Sign Epistasis Controlling Ovariole Number Between Two Drosophila Species [PDF]
Genetics, 2006 Abstract Identifying the genes underlying genetically complex traits is of fundamental importance for medicine, agriculture, and evolutionary biology. However, the level of resolution offered by traditional quantitative trait locus (QTL) mapping is usually coarse. We analyze here a trait closely related to fitness, ovariole number.
Virginie, Orgogozo +2 more
openaire +2 more sources
Percolation in protein sequence space. [PDF]
PLoS ONE, 2017 The currently known protein sequences are not distributed equally in sequence space, but cluster into families. Analyzing the cluster size distribution gives a glimpse of the large and unknown extant protein sequence space, which has been explored during
Patrick C F Buchholz +2 more
doaj +1 more source
Historical contingency and entrenchment in protein evolution under purifying selection [PDF]
, 2014 The fitness contribution of an allele at one genetic site may depend on alleles at other sites, a phenomenon known as epistasis. Epistasis can profoundly influence the process of evolution in populations under selection, and can shape the course of ...
McCandlish, David M. +2 more
core +2 more sources
Dynamic Epistasis under Varying Environmental Perturbations [PDF]
, 2014 Epistasis describes the phenomenon that mutations at different loci do not have independent effects with regard to certain phenotypes. Understanding the global epistatic landscape is vital for many genetic and evolutionary theories. Current knowledge for
Barker, Brandon, Gu, Zhenglong, Xu, Lin
core +7 more sources
Nature Communications, 2023 An important challenge in genetics, evolution and biotechnology is to understand and predict how mutations combine to alter phenotypes, including molecular activities, fitness and disease.
Xuan Xie +4 more
doaj +1 more source
The Changing Geometry of a Fitness Landscape Along an Adaptive Walk
, 2013 It has recently been noted that the relative prevalence of the various kinds of epistasis varies along an adaptive walk. This has been explained as a result of mean regression in NK model fitness landscapes. Here we show that this phenomenon occurs quite
Crona, Kristina, Greene, Devin
core +6 more sources
Mitotic recombination accelerates adaptation in the fungus Aspergillus nidulans. [PDF]
PLoS Genetics, 2007 Understanding the prevalence of sexual reproduction in eukaryotes is a hard problem. At least two aspects still defy a fully satisfactory explanation, the functional significance of genetic recombination and the great variation among taxa in the relative
Sijmen E Schoustra +3 more
doaj +1 more source
eLife, 2022 Bacterial pathogens show high levels of chromosomal genetic diversity, but the influence of this diversity on the evolution of antibiotic resistance by plasmid acquisition remains unclear. Here, we address this problem in the context of colistin, a ‘last
Pramod K Jangir +7 more
doaj +1 more source
Mechanisms of protein sequence divergence and incompatibility. [PDF]
PLoS Genetics, 2013 Alignments of orthologous protein sequences convey a complex picture. Some positions are utterly conserved whilst others have diverged to variable degrees. Amongst the latter, many are non-exchangeable between extant sequences.
Alon Wellner +2 more
doaj +1 more source