Results 31 to 40 of about 7,799 (146)
Protein Complexes Form a Basis for Complex Hybrid Incompatibility
Frontiers in Genetics, 2021 Proteins are the workhorses of the cell and execute many of their functions by interacting with other proteins forming protein complexes. Multi-protein complexes are an admixture of subunits, change their interaction partners, and modulate their ...
Krishna B. S. Swamy +3 more
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Statistical Physics of Evolutionary Trajectories on Fitness Landscapes [PDF]
, 2013 Random walks on multidimensional nonlinear landscapes are of interest in many areas of science and engineering. In particular, properties of adaptive trajectories on fitness landscapes determine population fates and thus play a central role in ...
Manhart, Michael, Morozov, Alexandre V.
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Promiscuity‐Guided Enzyme Evolution via Substrate Multiplexed Screening
Angewandte Chemie, EarlyView.Through historical context and recent examples, this Minireview summarizes the strengths, limitations, and practical considerations for the implementation of substrate multiplexed screening (SUMS) in enzyme evolution. ABSTRACT An enzyme's ability to react with diverse substrates while maintaining high yield and selectivity, termed “substrate ...
Holly A. Weilbaker +3 more
wiley +2 more sources
PLoS Biology, 2017 Independently evolving populations may adapt to similar selection pressures via different genetic changes. The interactions between such changes, such as in a hybrid individual, can inform us about what course adaptation may follow and allow us to ...
Jasmine Ono +2 more
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Red Queen dynamics with non-standard fitness interactions. [PDF]
PLoS Computational Biology, 2009 Antagonistic coevolution between hosts and parasites can involve rapid fluctuations of genotype frequencies that are known as Red Queen dynamics. Under such dynamics, recombination in the hosts may be advantageous because genetic shuffling can quickly ...
Jan Engelstädter, Sebastian Bonhoeffer
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PLoS Genetics, 2019 Characterizing the fitness landscape, a representation of fitness for a large set of genotypes, is key to understanding how genetic information is interpreted to create functional organisms.
Victoria O Pokusaeva +13 more
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PLoS Pathogens, 2021 Linkage effects in a multi-locus population strongly influence its evolution. The models based on the traveling wave approach enable us to predict the average speed of evolution and the statistics of phylogeny.
Gabriele Pedruzzi, Igor M Rouzine
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Effects of Epistasis and Pleiotropy on Fitness Landscapes
, 2013 The factors that influence genetic architecture shape the structure of the fitness landscape, and therefore play a large role in the evolutionary dynamics. Here the NK model is used to investigate how epistasis and pleiotropy -- key components of genetic
A Dawid +15 more
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Properties of selected mutations and genotypic landscapes under Fisher's Geometric Model
, 2014 The fitness landscape - the mapping between genotypes and fitness - determines properties of the process of adaptation. Several small genetic fitness landscapes have recently been built by selecting a handful of beneficial mutations and measuring fitness
Achaz, Guillaume +3 more
core +3 more sources
, 2015 Epistasis is a key concept in the theory of adaptation. Indicators of epistasis are of interest for large system where systematic fitness measurements may not be possible. Some recent approaches depend on information theory.
Crona, Kristina
core +3 more sources