Results 71 to 80 of about 1,606,386 (353)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A ministry of (not-so-silly) walks: Investigating classifier handshapes for animate referents in DGS

Open Linguistics
Across sign languages, classifier predicates depict the movement, location, or manipulation of (in-)animate entities. Each classifier predicate contains a classifier handshape that represents a referent based on one or more of its salient semantic and/or
Lettow Isabeau, Loos Cornelia
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

“Taidokas vuorovaikuttaja treenaa osaamistaan” – vuorovaikutusosaamisen kehittämisen diskurssit koulutuspalvelujen kuvauksissa [PDF]

VAKKI Publications, 2018
Public discourse in the media about the future demands and requirements of working life on individuals often highlights the ever-increasing importance of interactional skills.
Elina Tapio, Marjo-Leea Alapuranen, Marika Rauhansalo, Maarit Siromaa   +3 more
doaj  

American Sign Language Interpreters and their Influence on the Hearing World [PDF]

, 2018
This honors thesis is going to discuss the hearing community’s perception of American Sign Language and by association the hearing community’s perception of the Deaf community.
Groat, Madison
core   +1 more source

Automatic recognition of fingerspelled words in British Sign Language [PDF]

, 2009
We investigate the problem of recognizing words from video, fingerspelled using the British Sign Language (BSL) fingerspelling alphabet. This is a challenging task since the BSL alphabet involves both hands occluding each other, and contains signs ...
Everingham, M., Liwicki, S.
core   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Głusi i tłumacze PJM o tłumaczeniu języka migowego w Polsce kiedyś i dziś

Między Oryginałem a Przekładem, 2021
Sign Language Interpreting in the Opinions of Deaf Persons and Polish Sign Language Interpreters The article presents the results of a research conducted among 12 deaf people and 11 Polish sign language interpreters, aimed at depicting the state-of ...
Aleksandra Kalata-Zawłocka
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source