Results 51 to 60 of about 556,000 (299)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Sensors, 2020 Sign languages are developed around the world for hearing-impaired people to communicate with others who understand them. Different grammar and alphabets limit the usage of sign languages between different sign language users.
Shigeyuki Tateno +2 more
doaj +1 more source
How Much Can Classifiers Be Analogous To Their Referents? [PDF]
, 2013 Sign Language poetry is especially valued for its presentation of strong visual images. Here, we explore the highly visual signs that British Sign Language and American Sign Language poets create as part of the \u27classifier system\u27 of their ...
Napoli, Donna Jo, Sutton-Spence, R.
core +2 more sources
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Sign languages of the Soviet Union: a comparison of Georgian, Russian, and Tajik Sign Languages
Open LinguisticsMany signing communities in countries that once formed part of the Soviet Union share a common deaf institutional history. The sign languages of these communities have been influenced by Russian Sign Language, which was taught and used to varying degrees
Power Justin M. +3 more
doaj +1 more source
New Insights Into Mouthings: Evidence From a Corpus-Based Study of Russian Sign Language
Frontiers in Psychology, 2022 While some aspects of mouthings have been previously investigated, many topics in the use of this cross-modal contact phenomenon in sign languages remain un(der)studied, and not much is known about mouthings in Russian Sign Language (RSL), in particular.
Anastasia Bauer, Masha Kyuseva
doaj +1 more source
Adapting Tests of Sign Language Assessment for Other Sign Languages—A Review of Linguistic, Cultural, and Psychometric Problems [PDF]
, 2008 Given the current lack of appropriate assessment tools for measuring deaf children's sign language skills, many test developers have used existing tests of other sign languages as templates to measure the sign language used by deaf people in their ...
Haug, T., Mann, W.
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Frontiers in Communication, 2021 Language is produced by bodies that evolved to fulfill a variety of functions, most of them non-communicative. Vestigial influences of adaptation for quadrupedal locomotion are still affecting bimanual actions, and have consequences on manual ...
Oksana Tkachman +3 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source