Results 51 to 60 of about 6,144,235 (236)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
TEACHING SIGN LANGUAGE FOR HEALTHCARE WITHIN A LANGUAGES FOR SPECIFIC PURPOSES FRAMEWORK [PDF]
Journal of Languages for Specific Purposes, 2019 Languages for specific purposes is a subdiscipline of applied linguistics that looks at language learning and teaching for a specific education or training need.
Keren Cumberbatch
doaj
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Handling Sign Language Data: The Impact of Modality
Frontiers in Psychology, 2019 Natural languages come in two different modalities. The impact of modality on the grammatical structure and linguistic theory has been discussed at great length in the last 20 years.
Josep Quer, Markus Steinbach
doaj +1 more source
Chapter Sign language ideologies: Practices and politics
, 2020 This book focuses on how sign language ideologies influence, manifest in, and are challenged by communicative practices. Sign languages are minority languages using the visual-gestural and tactile modalities, whose affordances are very different from ...
Kusters, Annelies +3 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Sign languages of the Soviet Union: a comparison of Georgian, Russian, and Tajik Sign Languages
Open LinguisticsMany signing communities in countries that once formed part of the Soviet Union share a common deaf institutional history. The sign languages of these communities have been influenced by Russian Sign Language, which was taught and used to varying degrees
Power Justin M. +3 more
doaj +1 more source
Sensors, 2020 Sign languages are developed around the world for hearing-impaired people to communicate with others who understand them. Different grammar and alphabets limit the usage of sign languages between different sign language users.
Shigeyuki Tateno +2 more
doaj +1 more source