Results 201 to 210 of about 797,150 (338)

A Model of Epigenetic Inheritance Accounts for Unexpected Adaptation to Unforeseen Challenges

open access: yesAdvanced Science, EarlyView.
A general model of inheriting changes that are acquired during the lifetime of individuals demonstrates tremendous benefits to the population, including escape from extinction in changing environments. Contrasting the model with experimental data shows that inheritance of acquired changes enables rapid adaptation to unforeseen challenges, and accounts ...
Dino Osmanović   +2 more
wiley   +1 more source

MRAS: Master Regulator Analysis of Alternative Splicing

open access: yesAdvanced Science, EarlyView.
This study developed a computational approach called MRAS, designed to identify master regulators of splicing differences across various biological contexts. In this framework, altered RBP expression, rather than spliceosomal mutations or other modifications, plays a central role in driving these splicing differences.
Lei Zhou   +9 more
wiley   +1 more source

DNA–Protein Binding is Dominated by Short Anchoring Elements

open access: yesAdvanced Science, EarlyView.
This study delineate the binding mechanism of transcription factors (TFs) in the genome with the knowledge obtained at thermodynamic equilibrium conditions. Through KaScape experiments, combined with the AEEscape algorithm development, they identified the minimal dominant interacting elements, termed as Anchoring Elements (AEs).
Hong Chen   +3 more
wiley   +1 more source

Online machine learning modeling and predictive control of nonlinear systems with scheduled mode transitions

open access: yesAIChE Journal, Volume 69, Issue 2, February 2023., 2023
Abstract This work develops a model predictive control (MPC) scheme using online learning of recurrent neural network (RNN) models for nonlinear systems switched between multiple operating regions following a prescribed switching schedule. Specifically, an RNN model is initially developed offline to model process dynamics using the historical ...
Cheng Hu, Yuan Cao, Zhe Wu
wiley   +1 more source

Advancements in Bio‐Integrated Flexible Electronics for Hemodynamic Monitoring in Cardiovascular Healthcare

open access: yesAdvanced Science, EarlyView.
This review explores the cutting‐edge development of bio‐integrated flexible electronics for real‐time hemodynamic monitoring in cardiovascular healthcare. It covers key physiological indicators, innovative sensing mechanisms, and materials considerations. This paper highlights the application of both invasive and non‐invasive devices in cardiovascular
Ke Huang, Zhiqiang Ma, Bee Luan Khoo
wiley   +1 more source

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