Results 221 to 230 of about 5,727,454 (298)

WCN24-828 PHASE 3 COMMODORE TRIALS OF CROVALIMAB IN PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH): IMPACT ON KIDNEY FUNCTION

Kidney International Reports
Rocio Soldati, Sasha Sreckovic, Cristian Brocchieri, Patty Leon, Nadiesh Balachandran, Marianne Uguen, Simon Buatois   +6 more
doaj   +1 more source

LED Railway Signal Detection Rather Than Recognition is Affected by Both Refractive and Non-refractive Blur. [PDF]

Ophthalmic Physiol Opt
Choy J, Nguyen T, Boon MY, Honson VJ, Dain SJ.   +4 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Signal Detection Using Change Point Analysis to Identify Safety Signals from Spontaneous Reports in Aortic Stent Grafts in Japan. [PDF]

J Med Syst
Takahashi K, Yokoi H, Mikami F, Satomi T, Seki M, Niwa TT, Hanaoka H, Inaba Y, Koide D.   +8 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Quantitative method of pipeline magnetic leakage internal signal detection on the basis of an improved neural network. [PDF]

Sci Rep
Wang G, Bei S, Zuo Y, Zhang H.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Review of Pulsation Signal Detection and Applications in Dynamic Photoacoustic Imaging. [PDF]

Biosensors (Basel)
Zheng W, Huang C, Xia J.
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source