Results 121 to 130 of about 4,029,563 (257)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Interactive learning of natural sign language with radar
IET Radar, Sonar & NavigationOver the past decade, there have been great advancements in radio frequency sensor technology for human–computer interaction applications, such as gesture recognition, and human activity recognition more broadly.
Emre Kurtoğlu +5 more
doaj +1 more source
Quantification des images couleur par un algorithme de classification crédibiliste [PDF]
, 2005 Nous proposons un algorithme de quantification des images couleur fondé sur la théorie de l'évidence. Dans ce cadre, le problème de quantification est vu comme un problème de classification non supervisée dans l'espace couleur.
COLOT, Olivier +3 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Séparation adaptative de sources dans l'espace signal
, 1995 Nous explorons la possibilité de coupler un algorithme adaptatif de séparation de sources avec un algorithme adaptatif de projection de projection sur l'espace signal afin de tirer parti d'un nombre de capteurs supérieur au nombre de sources.
CARDOSO, Jean-Francois
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Le lissage H∞ : une alternative au filtrage de Kalman pour le rehaussement du signal de parole ?
, 2005 - La mise en oeuvre d'un filtre de Kalman repose sur des hypothèses fortes sur le processus générateur et le bruit d'observation du système. En effet, ils doivent être tous les deux blancs et gaussiens et leurs variances connues a priori.
GRIVEL, E. +3 more
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Low frequency signal classification using clustering methods
The article considers the problem of low frequency signal classification, as sound or vibration pattern footprints may describe types of objects very well.
Doroshenko, A.Yu., Rahozin, D.V.
core
An experiment in audio classification from compressed data [PDF]
, 2004 In this paper we present an algorithm for automatic classification of sound into speech, instrumental sound/ music and silence. The method is based on thresholding of features derived from the modulation envelope of the frequency limited audio signal ...
Murphy, Noel +3 more
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