Results 121 to 130 of about 44,408 (304)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Revolutionize 3D-Chip Design With Open3DFlow, an Open-Source AI-Enhanced Solution

IEEE Open Journal of Circuits and Systems
The escalating demand for high-performance and energy-efficient electronics has propelled 3D integrated circuits (3D ICs) as a promising solution. However, major obstacles have been the lack of specialized electronic design automation (EDA) software and ...
Yifei Zhu, Zhenxuan Luan, Dawei Feng, Weiwei Chen, Lei Ren, Zhangxi Tan   +5 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Glypican-3 regulated epithelial mesenchymal transformation-related genes in osteosarcoma: based on comprehensive tumor microenvironment profiling

Frontiers in Immunology
IntroductionOsteosarcoma (OS) is the most common primary bone malignancy, predominantly affecting children and adolescents. Current treatment approaches have limited efficacy, with a 5-year survival rate of approximately 60%.
Jiaming Zhang, Wei Wang
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

InP/Si3N4 Hybrid Integrated Lasers for RF Local Oscillator Signal Generation in Satellite Payloads

Photonics
This paper presents an integrated tunable hybrid multi-laser module designed to simultaneously generate multiple radiofrequency (RF) local oscillator (LO) signals through optical heterodyning. The device consists of five hybrid InP/Si3N4 integrated lasers, each incorporating an intracavity wavelength-selective optical filter formed by two micro-ring ...
Cesar, Jessica, ZARZUELO GARCIA, Alberto, GUZMAN MARTINEZ, ROBINSON CRUZOE, Mitsolidou, Charoula, Visscher, Ilka, Timens, Roelof Bernardus, van Dijk, Paul, Roeloffzen, Chris, Gonzalez Guerrero, Luis, Delgado Mendinueta, Jose Manuel, CARPINTERO DEL BARRIO, GUILLERMO   +10 more
openaire   +4 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

A Study on Signal Integrity of Fine Lines in Package Substrate [PDF]

, 2015
With the advance of IC manufacturing process, the density of circuit gets higher year by year. In order to increase the amount of transmitted information in limited space, it must reduce the width of transmission line.
Wu, Po-I
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source