Results 41 to 50 of about 249,513 (267)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Survey on positioning technology based on signal of opportunity from low earth orbit

Frontiers in Physics
Positioning, Navigation, and Timing (PNT) services are essential for supporting various aspects of modern society. Fields such as communications, transportation, and military operations heavily rely on accurate and reliable PNT services, with this ...
Jiawei He, Jiawei He, Shaojie Ni, Shaojie Ni, Honglei Lin, Honglei Lin, Zhe Liu, Zhe Liu, Zhibin Xiao, Zhibin Xiao   +9 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

A Study on Anti-Jamming Algorithms in Low-Earth-Orbit Satellite Signal-of-Opportunity Positioning Systems for Unmanned Aerial Vehicles

Drones
Low-Earth-Orbit (LEO) satellite Signal-of-Opportunity (SOP) positioning technology has gradually matured to meet the accuracy requirements for unmanned aerial vehicle (UAV) positioning in daily scenarios.
Lihao Yao, Honglei Qin, Boyun Gu, Guangting Shi, Hai Sha, Mengli Wang, Deyong Xian, Feiqiang Chen, Zukun Lu   +8 more
doaj   +1 more source

Cramér–Rao lower bound for ATSC signal‐based passive radar systems

Electronics Letters, 2019
In multistatic passive radar systems, the Cramér–Rao lower bound (CRLB) can be used to select the optimal illuminator of opportunity so that it provides the best estimation accuracy for target parameters.
M. Alslaimy, G.E. Smith
doaj   +1 more source

Underwater Localization via Wideband Direction-of-Arrival Estimation Using Acoustic Arrays of Arbitrary Shape

Sensors, 2020
Underwater sensing and remote telemetry tasks necessitate the accurate geo-location of sensor data series, which often requires underwater acoustic arrays. These are ensembles of hydrophones that can be jointly operated in order to, e.g., direct acoustic
Elizaveta Dubrovinskaya, Veronika Kebkal, Oleksiy Kebkal, Konstantin Kebkal, Paolo Casari   +4 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source