Results 61 to 70 of about 1,365 (214)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

KDFE: Robust KNN-Driven Fusion Estimator for LEO-SoOP Under Multi-Beam Phased-Array Dynamics

Remote Sensing
Accurate Doppler frequency estimation for Low Earth Orbit (LEO)-based Signals of Opportunity (SoOP) positioning faces significant challenges from extreme dynamics (±40 kHz Doppler shift, 0.4 Hz/ms fluctuation) and severe SNR fluctuations induced by multi-
Jiaqi Yin, Ruidan Luo, Xiao Chen, Linhui Zhao, Hong Yuan, Guang Yang   +5 more
doaj   +1 more source

Target Localization by Resolving the Time Synchronization Problem in Bistatic Radar Systems Using Space Fast-Time Adaptive Processor

EURASIP Journal on Advances in Signal Processing, 2009
The proposed technique allows the radar receiver to accurately estimate the range of a large number of targets using a transmitter of opportunity as long as the location of the transmitter is known.
D. Madurasinghe, A. P. Shaw
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Using an Activity Based on Constructivism To Help Students Develop a More Integrated Understanding of Cell Signaling Pathways

Journal of Microbiology & Biology Education, 2019
In subjects like cell biology, genetics, and immunology, a solid understanding of signal transduction is key to mastering new content.  Often times students’ approach to learning signal transduction pathways relies heavily on memorization.  In this paper,
Laura MacDonald, Verónica A. Segarra, Amanda Solem   +2 more
doaj   +1 more source

Multicarrier Modulation as a Navigation Signal of Opportunity [PDF]

2008 IEEE Aerospace Conference, 2008
The global positioning system (GPS) generally provides worldwide high-accuracy positioning. However, GPS requires lines of sight to multiple satellites and may be blocked or jammed, hence backup navigation techniques are of interest. Navigation via signals of opportunity uses existing radio infrastructure as ad hoc navigational beacons.
Richard K. Martin, Jamie Velotta, John Raquet   +2 more
openaire   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Signal Transduction in the Footsteps of Goethe and Schiller

Cell Communication and Signaling, 2009
The historical town of Weimar in Thuringia, the "green heart of Germany" was the sphere of Goethe and Schiller, the two most famous representatives of German literature's classic era.
Feller Stephan M, Ehrhardt Christina, Giehl Klaudia, Kieser Arnd, Thiel Gerald, Serfling Edgar, Entschladen Frank, Lindquist Jonathan A, Friedrich Karlheinz, Ullrich Oliver, Schaper Fred, Janssen Ottmar, Hass Ralf   +12 more
doaj   +1 more source