Results 121 to 130 of about 3,392,560 (298)
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
Molecular HorticulturePeptide hormones are defined as small secreted polypeptide-based intercellular communication signal molecules. Such peptide hormones are encoded by nuclear genes, and often go through proteolytic processing of preproproteins and post-translational ...
Zhenbiao Zhang +12 more
doaj +1 more source
Signal peptide prediction statistics for 5 Leishmania species.
Signal peptide prediction statistics for 5 Leishmania species.
Toby J. Gibson (17980281) +2 more
core +1 more source
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
Variation of Signal Peptide by Transcript Variation and Alternative Splicing
, 2013 Sixteen TUs are represented in both categories. These TUs contain multiple transcripts using signal peptide coding regions generated from distinct regions of the genome while alternative transcripts within the same TU exclude these signal peptide coding ...
Fasheng Zhang (13974) +10 more
core +1 more source
Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease
FEBS Letters, EarlyView.Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim +4 more
wiley +1 more source
Signal Peptides and Their Fragments in Post-Translation: Novel Insights of Signal Peptides
International Journal of Molecular SciencesSignal peptides (SPs), peptide sequences located at the N-terminus of newly synthesized proteins, are primarily known for their role in targeting proteins to the endoplasmic reticulum (ER). It has traditionally been assumed that cleaved SPs are rapidly degraded and digested near the ER.
openaire +2 more sources
Signal peptide is a conserved feature of homologous proteins.
, 2013 Homologous proteins of human/mouse, human/fruit fly, and human/C. elegans were extracted from HomoloGene triplets. The proportion of matching protein pairs, in which both proteins have or lack a signal peptide, was calculated for each pair of organisms ...
Eddo Kim (24719) +2 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Peptide-conjugated micelles as a targeting nanocarrier for gene delivery
, 2017 The aim of this study was to develop peptide-conjugated micelles possessing epidermal growth factor receptor (EGFR) targeting ability for gene delivery.
Lin, Wen Jen;Chien, Wei Hsuan, 林文貞
core +1 more source