Results 211 to 220 of about 3,392,560 (298)

Pleiotropic effects of signal peptide peptidase A (<i>sppA</i>) gene deletion on membrane homeostasis, gliding motility, and virulence in <i>Flavobacterium columnare</i>. [PDF]

Front Vet Sci
Zhu R, Zhong L, Xun Y, Zheng S, Zhu Y, Cai W.   +5 more
europepmc   +1 more source

Frailty Predicts Incident Osteoporotic Fractures in Veterans with Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective Rheumatoid arthritis (RA) is associated with an increased risk of frailty and osteoporosis, but the relationship between frailty and incident osteoporotic fractures in RA is underexplored. Methods Data were from the Veterans Affairs (VA) Rheumatoid Arthritis Registry. Frailty was measured using the VA Frailty Index (VAFI).
Katherine D. Wysham, Hannah F. Brubeck, Aaron Baraff, Punyasha Roul, Namrata Singh, James S. Andrews, Grant W. Cannon, Gary A. Kunkel, Ted R. Mikuls, Bryant R. England, Dolores M. Shoback, Patricia P. Katz, Jose M. Garcia, Ariela R. Orkaby, Joshua F. Baker   +14 more
wiley   +1 more source

Dimeric architecture and membrane thinning govern substrate recognition by human signal peptide peptidase

Lea S, Bryant O, Sergejevs N, Giacomo F, Robson-Tull J, Deme J, Forrest L, Carvalho P.   +7 more
europepmc   +1 more source

Clinical Characteristics and Concordance of Anti‐MDA5 Antibodies: A Multicenter Australian Study

Arthritis Care &Research, EarlyView.
Objective In Australia, anti‐MDA5 antibodies are exclusively tested by a line immunoblot assay (LIA). The clinical concordance of an LIA‐positive anti‐MDA5 result is unclear. We aimed to describe the clinical features and determine the clinical concordance of patients with anti‐MDA5 antibodies. Methods Electronic records of a multisite cohort (patients
Syed B. Ali, Thomas Khoo, Keeran Shivakumar, Adam Caroll, Lauren Hender, Dimitra Beroukas, Kim Griggs, Celina Jin, Theo De Malmanche, Jessica Day, Gabor Major, Vidya Limaye   +11 more
wiley   +1 more source

Modulating Purothionin Accumulation and Signal Peptide Cleavage Fine-Tunes Wheat Flour Gluten Properties to Improve Cookie-Making Quality. [PDF]

Adv Sci (Weinh)
Liu Y, Chang S, Zhang Z, Kang T, Liu M, Zong Y, Ni F, Bao Y, Zhang R, Zhang X, Du J, Xin M, Hu Z, Liu J, Ni Z, Sun Q, Yao Y.   +16 more
europepmc   +1 more source

Associations of Frailty With the Risk of Incident Cancer and Cancer‐Related Mortality in Veterans With Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective This study investigated the association between frailty and cancer incidence and mortality in patients with rheumatoid arthritis (RA). It aimed to identify how frailty influences cancer risk and cancer‐specific outcomes. Methods This retrospective cohort study analyzed data from the Veterans’ Affairs Rheumatoid Arthritis Registry (2002–2023).
Bhavik Bansal, Aaron Baraff, Katherine Wysham, James S. Andrews, Bryant R. England, Ted R. Mikuls, Joshua Baker, Kaleb Michaud, Alexa Meara, Una Makris, Carolyn Presley, Ariela Orkaby, Namrata Singh   +12 more
wiley   +1 more source

Signal Peptide of Human Serum Albumin (residues 1-18) Forms Amyloid-like Aggregates. [PDF]

ACS Omega
Thakur DC, Saumya KU, Singh VK, Giri R.
europepmc   +1 more source

Patients Improve, Patterns Persist: Longitudinal Stability of Rheumatoid Arthritis Joint Involvement Patterns

Arthritis Care &Research, EarlyView.
Objective Rheumatoid arthritis is a heterogeneous disease. Data‐driven approaches, from synovial histology to joint involvement patterns (JIPs), have sought to define clinically meaningful subgroups. Whether these subgroups represent stable phenotypes or transient disease states remains unclear.
Tjardo Maarseveen, Yasuo Nagafuchi, Kristina Lend, Seyam Alemyar, Herman Kasper Glas, Gerdur Gröndal, Bjorn Gudbjornsson, Espen A. Haavardsholm, Kim Hørslev Petersen, Jon Lampa, Merete Lund Hetland, Dan Nordström, Mike Nurmohamed, Mikkel Østergaard, Anna Rudin, Marte Schrumpf Heiberg, Tuulikki Sokka‐Isler, Till Uhlig, Josien van Dieren, Ronald van Vollenhoven, Tom Huizinga, Marcel J. T. Reinders, Sytske Anne Bergstra, Erik van den Akker, Rachel Knevel   +24 more
wiley   +1 more source

Functional Characterization of a Signal Peptide Peptidase in <i>Phaffia rhodozyma</i> Reveals a Potential Role in Protein Stress Response but Not in Activation of the SREBP Ortholog Sre1. [PDF]

Int J Mol Sci
Baeza M, Gómez M, Apariz G, Barahona S, Alcaíno J.   +4 more
europepmc   +1 more source

Conformational Switching of Proteins on Material Surfaces Enabled by Peptide‐Oriented Adsorption

Advanced Functional Materials, EarlyView.
Responsive biointerfaces could be achieved using conformationally responsive proteins; however, their interconversion can be lost upon surface adsorption. Herein, we demonstrate that the incorporation a Au binding peptide into calmodulin allows for binding control on Au wherein the protein retains conformational switching. This capability was confirmed
Sakthirupini Ramamurthy, Kyle B. Meerbott, Lorenzo Travaglini, Garima S. Dobhal, Artur Sawicki, Marc R. Knecht, Tiffany R. Walsh, Dominic J. Glover   +7 more
wiley   +1 more source