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The molecular evolution of signal peptides

Gene, 2000
Signal peptides direct mature peptides to their appropriate cellular location, after which they are cleaved off. Very many random alternatives can serve the same function. Of all coding sequences, therefore, signal peptides might come closest to being neutrally evolving.
E J, Williams, C, Pal, L D, Hurst
openaire   +2 more sources

Peptide signaling in vascular development

Current Opinion in Plant Biology, 2007
In plants and animals, putative small peptide ligands have been suggested to play crucial roles in development as signal molecules of cell-cell communication. Recent studies of CLAVATA3/ENDOSPERM SURROUNDING REGION (CLE) genes and their products have revealed that distinctive dodeca-CLE peptide ligands function in various developmental processes.
Hiroo, Fukuda   +2 more
openaire   +2 more sources

Plant peptides in defense and signaling

Peptides, 2014
This review focuses on plant peptides involved in defense against pathogen infection and those involved in the regulation of growth and development. Defense peptides, defensins, cyclotides and anti-microbial peptides are compared and contrasted. Signaling peptides are classified according to their major sites of activity. Finally, a network approach to
MARMIROLI, Nelson, MAESTRI, Elena
openaire   +3 more sources

Plant peptide hormone signalling

Essays in Biochemistry, 2015
The ligand–receptor-based cell-to-cell communication system is one of the most important molecular bases for the establishment of complex multicellular organisms. Plants have evolved highly complex intercellular communication systems. Historical studies have identified several molecules, designated phytohormones, that function in these processes ...
Ayane, Motomitsu   +2 more
openaire   +2 more sources

The ins and outs of peptide signaling

Trends in Microbiology, 1998
Many bacteria communicate by secreting and responding to extracellular peptides (pheromones). Some peptide pheromones act via receptors on the cell surface, which are often membrane-bound histidine protein kinases. Other peptide pheromones are transported into the cell by an oligopeptide permease and interact with intracellular receptors to modulate ...
B A, Lazazzera, A D, Grossman
openaire   +2 more sources

Peptides as Neuronal Signalling Molecules

1992
Neuropeptides form a major class of messenger substances in nervous systems. Current research suggests that neuropeptides playa key role in synaptic signalling and allow specific subsystems of the brain to communicate. In addition to the classical synaptic mechanisms, information transfer can also occur via the extracellular space (Agnati et al.
Zieglgänsberger, W.   +3 more
openaire   +2 more sources

Circulating signal peptides

Cardiovascular Endocrinology, 2013
It is well documented that signal peptides (SPs) play an important role in the cellular processing and secretion of peptides and proteins. During translation-associated translocation into the endoplasmic reticulum, SP are cleaved from the nascent proprotein and, with a few notable exceptions, it ...
Chris J. Pemberton, Torsten Kleffmann
openaire   +1 more source

Signal Peptide Peptidases

2007
Signal peptide peptidases (SPPs) are the most recently identified members of a protease family of integral membrane proteins that includes the intensively studied presenilin 1 (PS1) and presenilin (PS2) proteins. There are 5 human genes encoding SPPs which can be divided into two branches based on homology and initial functional studies.
Todd E. Golde   +2 more
openaire   +1 more source

Development of an in Vitro Screening System for Synthetic Signal Peptide in Mammalian Cell-Based Protein Production

Applied Microbiology and Biotechnology, 2022
Gyun Min Lee, Yeon-Gu Kim, Hoon-Min Lee
exaly  

Take Me Home, Protein Roads: Structural Insights Into Signal Peptide Interactions During ER Translocation

International Journal of Molecular Sciences, 2021
Friedrich Förster, A Manuel Liaci
exaly  

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