Results 91 to 100 of about 21,583,165 (357)

A stepwise emergence of evolution in the RNA world

open access: yesFEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

Statistical Digital Signal Processing and Modeling

open access: yes, 1996
From the Publisher: The main thrust is to provide students with a solid understanding of a number of important and related advanced topics in digital signal processing such as Wiener filters, power spectrum estimation, signal modeling and adaptive ...
M. Hayes
semanticscholar   +1 more source

Uniform attribute-content model

open access: yesThe Journal of Engineering, 2019
There have been growing needs for text processing, such as classifying, retrieving and clustering. The foundation of such a process is to extract features, which can best describe the text. Great progress has been made in text modelling. However, most of
Yingzhuo Xiang   +4 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

A Novel Multi-Angle SAR Imaging System and Method Based on an Ultrahigh Speed Platform

open access: yesSensors, 2019
Considering the difficulty of pulse repetition frequency (PRF) design in multi-angle SAR when using ultra-high speed platforms, a multi-angle SAR imaging system in a unified coordinate system is proposed.
Wensheng Chang   +4 more
doaj   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

open access: yesFEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche   +2 more
wiley   +1 more source

Signal Processing on Higher-Order Networks: Livin' on the Edge ... and Beyond [PDF]

open access: yesSignal Processing, 2021
Michael T. Schaub   +4 more
semanticscholar   +1 more source

A high maneuvering dim target detection algorithm based on non-uniform sub-aperture division and hybrid accumulation

open access: yesXibei Gongye Daxue Xuebao
The motion state of highly maneuverable small target is complex, with weak scattering energy and difficulty in maintaining signal coherence over long integration time, resulting in ineffective accumulation of target echo signal.
LI Jiajia   +3 more
doaj   +1 more source

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