Results 81 to 90 of about 1,039,011 (317)

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

open access: yesFEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke   +2 more
wiley   +1 more source

A working model for cytoplasmic assembly of H/ACA snoRNPs

open access: yesFEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Joint High-Resolution Range and DOA Estimation via MUSIC Method Based on Virtual Two-Dimensional Spatial Smoothing for OFDM Radar

open access: yesInternational Journal of Antennas and Propagation, 2018
For the purpose of target parameter estimation of the orthogonal frequency-division multiplexing (OFDM) radar, a high-resolution method of joint estimation on range and direction of arrival (DOA) based on OFDM array radar is proposed in this paper.
Rui Zhang   +5 more
doaj   +1 more source

A Novel Multi-Angle SAR Imaging System and Method Based on an Ultrahigh Speed Platform

open access: yesSensors, 2019
Considering the difficulty of pulse repetition frequency (PRF) design in multi-angle SAR when using ultra-high speed platforms, a multi-angle SAR imaging system in a unified coordinate system is proposed.
Wensheng Chang   +4 more
doaj   +1 more source

Signal Processing for a Cocktail Party Effect [PDF]

open access: bronze, 1969
O. M. M. Mitchell, CF ROSS, G. H. Yates
openalex   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

Uniform attribute-content model

open access: yesThe Journal of Engineering, 2019
There have been growing needs for text processing, such as classifying, retrieving and clustering. The foundation of such a process is to extract features, which can best describe the text. Great progress has been made in text modelling. However, most of
Yingzhuo Xiang   +4 more
doaj   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

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