Results 61 to 70 of about 153,573 (265)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A New Iterative Algorithm for Magnetic Motion Tracking

Sensors
Motion analysis is of great interest to a variety of applications, such as virtual and augmented reality and medical diagnostics. Hand movement tracking systems, in particular, are used as a human–machine interface. In most cases, these systems are based
Tobias Schmidt, Johannes Hoffmann, Moritz Boueke, Robert Bergholz, Ludger Klinkenbusch, Gerhard Schmidt   +5 more
doaj   +1 more source

Adaptive independent sticky MCMC algorithms

EURASIP Journal on Advances in Signal Processing, 2018
Monte Carlo methods have become essential tools to solve complex Bayesian inference problems in different fields, such as computational statistics, machine learning, and statistical signal processing.
Luca Martino, Roberto Casarin, Fabrizio Leisen, David Luengo   +3 more
doaj   +1 more source

Projection to Latent Spaces Disentangles Pathological Effects on Brain Morphology in the Asymptomatic Phase of Alzheimer's Disease

Frontiers in Neurology, 2020
Alzheimer's disease (AD) continuum is defined as a cascade of several neuropathological processes that can be measured using biomarkers, such as cerebrospinal fluid (CSF) levels of Aβ, p-tau, and t-tau.
Adrià Casamitjana, Paula Petrone, José Luis Molinuevo, José Luis Molinuevo, José Luis Molinuevo, Juan Domingo Gispert, Juan Domingo Gispert, Juan Domingo Gispert, Verónica Vilaplana   +8 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Multichannel Wiener filter in active sound‐navigation‐and‐ranging systems—A joint beamformer and matched filter approach

IET Radar, Sonar & Navigation
Conventional active SONAR systems often use beamformers and matched filters separately to extract bearing and range information from the received signal and offer a straightforward way of creating a two‐dimensional map of the environment.
Bastian Kaulen, Jan Abshagen, Gerhard Schmidt   +2 more
doaj   +1 more source

Sparse Signal Processing with Frame Theory

, 2012
Many emerging applications involve sparse signals, and their processing is a subject of active research. We desire a large class of sensing matrices which allow the user to discern important properties of the measured sparse signal. Of particular interest are matrices with the restricted isometry property (RIP).
openaire   +2 more sources