Results 51 to 60 of about 2,974,095 (188)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Remote Epilepsy Monitoring: Signal Quality and Reliability Comparative Analysis

IEEE Access
Epilepsy, a neurological condition affecting approximately 50 million individuals globally, is among the most common nervous system disorders. Electroencephalography (EEG) is vital for evaluating epilepsy, yet its intricate nature often restricts its ...
Theeban Raj Shivaraja, Rabani Remli, Wan Asyraf Wan Zaidi, Kalaivani Chellappan   +3 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

CHARACTERIZATION OF THE RELIABILITY OF RADIO COMMUNICATIONS WITH AIR TRAFFIC SERVICES

Научный вестник МГТУ ГА, 2016
Convert formulas to calculate the availability of the radio channel in a compact form, and the graph of depend-ence of the excess signal power at the receiver input over its actual sensitivity of the level of interference, while ensuring the required ...
E. I. Grigorieva, M. U. Zamaldinov
doaj  

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

MATHEMATICAL MODEL FOR ASSESSING THE QUALITY OF THE RADIO COMMUNICATION AIDS OPERATION IN CIVIL AVIATION

Научный вестник МГТУ ГА, 2016
The model for assessing radio communication aids reliability in the form of discrete semi-Markovian process which characteristics are determined by the characteristics of acting interferences is offered and justified in the article.
E. I. Grigorieva
doaj  

A High-Reliability Quantum Communication Protocol via Controllable-Signal Attenuation

Photonics
Since the protocol for counterfactual quantum communication was proposed, complete counterfactuality can be achieved as there are no physical particles in the transmission channel.
Yueying Zhang, Yanxiang Chen, Maolin Shi, Qun Zhou, Chao Liu   +4 more
doaj   +1 more source