Results 121 to 130 of about 3,801,818 (306)
Signal-Dependent Techniques for Non-Stationary Signal Sampling and Reconstruction
The paper describes the processing of non-stationary signals, which takes the advantages offered by the use of signaldependent techniques in sampling and analysis procedures. The level-crossing approach is exploited for signal sampling, whereby the local
Šāvelis, Rolands, Greitāns, Modris
core
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Signal Sampling According to Time-Varying Bandwidth
The paper addresses the problem of signal-dependent sampling of analogue signals according to local bandwidth. An extended sampling theorem is given which states that signals can be sampled non-uniformly and then perfectly reconstructed if spectrum ...
Šāvelis, Rolands, Greitāns, Modris
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Projective Blue‐Noise Sampling
, 2016 We propose projective blue‐noise patterns that retain their blue‐noise characteristics when undergoing one or multiple projections onto lower dimensional subspaces.
Ritschel, Tobias +3 more
core +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
A low‐cost Raspberry Pi based time domain reflectometer for fault detection in electric fences
IET Science, Measurement & TechnologyElectric fences used to create protected areas (PAs) are prone to faults that affect their operation. The conventional method of measuring the voltage of the fence periodically to detect faults and walking along the fence to locate the faults is ...
Gabriel Kiarie +2 more
doaj +1 more source