Results 151 to 160 of about 9,547,943 (379)
Cellular and Molecular Life SciencesThe Ca2+-selective transient receptor potential vanilloid 6 (TRPV6) channel plays a fundamental role in the female and male murine reproductive system.
Adela Sota +11 more
doaj +1 more source
FEBS Letters, EarlyView.Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia +5 more
wiley +1 more source
Toward an integrated map of genetic interactions in cancer cells
Molecular Systems Biology, 2018 Cancer genomes often harbor hundreds of molecular aberrations. Such genetic variants can be drivers or passengers of tumorigenesis and create vulnerabilities for potential therapeutic exploitation.
Benedikt Rauscher +5 more
doaj +1 more source
On the distribution of energy in noise- and signal-modulated waves. II. Simultaneous amplitude and angle modulation [PDF]
, 1952 David Middleton
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FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
HES1 potentiates high salt stress response as an enhancer of NFAT5-DNA binding
Communications BiologyHigh salt conditions and subsequent hyperosmolarity are injurious cellular stresses that can activate immune signaling. Nuclear factor of activated T-cells 5 (NFAT5) is an essential transcription factor that induces osmoprotective genes such as aldose ...
Hiroki Ryuno +6 more
doaj +1 more source
Signal corps research and development on automatic programming of digital computers [PDF]
, 1959 William F. Luebbert, Percy W. Collom
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Spence Revisited: Signaling and the Allocation of Individuals to Jobs [PDF]
Spence (1974a) considered a variant of his signaling model in which there are two types of jobs, and in which signaling can increase wealth by improving the allocation of individuals to jobs.
Timothy Perri
core
FEBS Letters, EarlyView.Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur +5 more
wiley +1 more source