Results 161 to 170 of about 5,103,566 (350)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Emotion recognition from physiological signals

, 2011
Khadidja Gouizi, F. Bereksi Reguig, Choubeila Maaoui   +2 more
openalex   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

305 CAR positive cell selection: A versatile approach to purify CAR-T cells using anti-linker monoclonal antibodies attached to cleavable magnetic beads

Journal for ImmunoTherapy of Cancer, 2023
Amrik Singh, Sarah L’Heureux, Jeremy Fisher   +2 more
doaj   +1 more source

Platelet-derived microparticles increase the interaction of colorectal cancer cells with the endothelium to promote metastatic events

Journal of Translational Medicine
Background The major challenge in colorectal cancer (CRC) therapy involves the formation of distant metastases, which represent the primary cause of treatment failure and patient death.
Izabela Papiewska-Pająk, Hassan Kassassir, Wiktoria Moczkowska, Marcin Braun, Anna Rybicka, Joanna Boncela, M. Anna Kowalska   +6 more
doaj   +1 more source

Electronic polarization-division demultiplexing based on digital signal processing in intensity-modulation direct-detection optical communication systems

, 2014
Kumiko Kikuchi
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Plastic hepatocyte states limit liver cancer development

Nature Communications
The liver has remarkable regenerative capacity owing to the boundless proliferative potential of hepatocytes. During liver injury, sustained regeneration must be balanced by mechanisms limiting overgrowth and tumorigenesis.
Lauren S. Strathearn, Yuki Hayata, Abhinav Illendula, Charles K. Hewett, Mingjia Chen, Guoshun He, María Escribano-Cebrián, Brianna Jarboe, Laura Gómez-Tomé, Nicola de Prisco, Michael Slifker, Satoshi Kawamura, Hayato Nakagawa, David Rossell, Ben Z. Stanger, Joan Font-Burgada   +15 more
doaj   +1 more source

Author response for "Hypothalamic insulin signalling as a nexus regulating mood and metabolism"

, 2021
Sasha Rawlinson, Zane B. Andrews
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source