Results 51 to 60 of about 624,213 (299)

Signatures and flatness.

Journal für die reine und angewandte Mathematik (Crelles Journal), 1993
Let \(Y\subset\mathbb{R}^ n\) be a codimension one analytic set, and fix a signature \(\sigma\) on \(\mathbb{R}^ n\backslash Y\) \((\sigma\) associates a \(\text{sign}+1\) or \(-1\) to each connected component of \(\mathbb{R}^ n\backslash Y)\). The signature \(\sigma\) is admissible at \(x\in Y\) when the germ \(\sigma_ x\) is induced by a germ of ...
ACQUISTAPACE, FRANCESCA, BROGLIA, FABRIZIO   +1 more
openaire   +3 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Combined Signature of the Urinary Microbiome and Metabolome in Patients With Interstitial Cystitis

Frontiers in Cellular and Infection Microbiology, 2021
Interstitial cystitis (IC) is a clinical syndrome characterized by frequency, urgency, and bladder pain or pelvic pain; however, the underlying pathophysiological mechanisms and diagnostic markers are unknown.
Hewei Xu, Hewei Xu, Nebiyu Elias Tamrat, Nebiyu Elias Tamrat, Jie Gao, Jie Gao, Jie Xu, Jie Xu, Yiduo Zhou, Yiduo Zhou, Sicong Zhang, Sicong Zhang, Zhengsen Chen, Zhengsen Chen, Yunpeng Shao, Yunpeng Shao, Liucheng Ding, Liucheng Ding, Baixin Shen, Baixin Shen, Zhongqing Wei, Zhongqing Wei   +21 more
doaj   +1 more source

A persistent neutrophil-associated immune signature characterizes post–COVID-19 pulmonary sequelae [PDF]

, 2022
Peter M. George, Anna Reed, Sujal R. Desai, Anand Devaraj, Tasnim Shahridan Faiez, S. G. Laverty, Amama Kanwal, Camille Esneau, Michael K. P. Liu, Faisal Kamal, William D‐C Man, Sundeep Kaul, Suveer Singh, Georgia Lamb, Fatima K. Faizi, Michael Schuliga, Jane Read, Thomas Burgoyne, Andreia Pinto, Jake Micallef, Émilie Bauwens, Julie Candiracci, Mhammed Bougoussa, Mariëlle Herzog, Lavanya Raman, Blerina Ahmetaj‐Shala, Stuart Turville, Anupriya Aggarwal, Hugo Farne, Alessia Dalla Pria, Andrew Aswani, Francesca Patella, Weronika E. Borek, Jane A. Mitchell, Nathan W. Bartlett, Arran Dokal, Xiao‐Ning Xu, Peter Kelleher, Anand Shah, Aran Singanayagam   +39 more
openalex   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Development and External Validation of a Novel Immune Checkpoint–Related Gene Signature for Prediction of Overall Survival in Hepatocellular Carcinoma

Frontiers in Molecular Biosciences, 2021
Objective: The purpose of this study was to develop and validate a novel immune checkpoint–related gene signature for prediction of overall survival (OS) in hepatocellular carcinoma (HCC).Methods: mRNA expression profiles and clinical follow-up ...
Enfa Zhao, Shimin Chen, Ying Dang
doaj   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Towards Signature-Only Signature Schemes [PDF]

, 2000
We consider a problem which was stated in a request for comments made by NIST in the FIPS97 document. The question is the following: Can we have a digital signature public key infrastructure where the public (signature verification) keys cannot be abused for performing encryption?
Adam Young, Moti Yung
openaire   +1 more source