Results 31 to 40 of about 722,278 (319)

Understanding drug resistance in chronic myeloid leukemia through the lens of leukemic stem cell states: insights from single-cell analyses

Haematologica
Despite the advent of potent tyrosine kinase inhibitors (TKIs), resistance and disease persistence remain significant clinical challenges in chronic myeloid leukemia (CML).
Vaidehi Krishnan, Pavithra Shyamsunder, Tiong S. Ong   +2 more
doaj   +1 more source

Direct Induction and Functional Maturation of Forebrain GABAergic Neurons from Human Pluripotent Stem Cells

Cell Reports, 2016
Gamma-aminobutyric acid (GABA)-releasing interneurons play an important modulatory role in the cortex and have been implicated in multiple neurological disorders.
Alfred Xuyang Sun, Qiang Yuan, Shawn Tan, Yixin Xiao, Danlei Wang, Audrey Tze Ting Khoo, Levena Sani, Hoang-Dai Tran, Paul Kim, Yong Seng Chiew, Kea Joo Lee, Yi-Chun Yen, Huck Hui Ng, Bing Lim, Hyunsoo Shawn Je   +14 more
doaj   +1 more source

A prognostic signature based on adenosine metabolism related genes for ovarian cancer

Frontiers in Oncology, 2022
BackgroundOvarian cancer is one of the most common cause of cancer death in women due to its late diagnosis and susceptibility to drug resistance. Adenosine (ADO) signaling plays a key role in immune activity and tumor progression.
Weifeng Liang, Chao Zhou, Jingshu Wang, Jing Zhao, Fang Liu, Guoqiang Wang, Chunwei Xu, Yuzi Zhang, Wenxian Wang, Shangli Cai, Yusheng Han, Lei Chang, Peihai Zhang   +12 more
doaj   +1 more source

Graded Signatures

, 2015
Motivated by the application of anonymous petitions, we formalize a new primitive called "graded signatures", which enables a user to consolidate a set of signatures on a message m originating from l different signers that are members of a PKI. We call the value $$l \in \mathbb {N}$$l∈N, the grade of the consolidated signature.
Aggelos Kiayias, Murat Osmanoglu, Qiang Tang 0005   +2 more
openaire   +2 more sources

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source

Integrating multiple machine learning methods to construct glutamine metabolism-related signatures in lung adenocarcinoma

Frontiers in Endocrinology, 2023
BackgroundGlutamine metabolism (GM) is known to play a critical role in cancer development, including in lung adenocarcinoma (LUAD), although the exact contribution of GM to LUAD remains incompletely understood.
Pengpeng Zhang, Shengbin Pei, Leilei Wu, Zhijia Xia, Qi Wang, Xufeng Huang, Zhangzuo Li, Jiaheng Xie, Mingjun Du, Haoran Lin   +9 more
doaj   +1 more source

New Concept Of Security E-Documents With Hybrid Method: Biometric Signature And DSA (Digital Signature Algorithm) [PDF]

, 2012
Exchange of electronic documents (e-documents) or documents in an e-mail on the internet has been widely used as a commercial transaction. To ensure e-document is still intact / authentic to the party verifier in transit on the network insecure one of ...
Ana, wahyuni
core  

Practical Short Signature Batch Verification [PDF]

, 2009
In many applications, it is desirable to work with digital signatures that are short, and yet where many messages from different signers be verified very quickly. RSA signatures satisfy the latter condition, but are generally thousands of bits in length.
Pedersen, Michael Østergaard, Hohenberger, Susan, Anna Lisa Ferrara, Susan Hohenberger, Matthew Green, Michael Østergaard Pedersen, Ferrara, Anna Lisa, Green, Matthew   +7 more
core   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

Discerning dangerous gain of function: most gain of function (GoF) research does not involve infectious microbes

Frontiers in Bioengineering and Biotechnology
The article reviews the use of the term “gain of function” (GoF) and “dangerous gain of function” (DGoF) in both the regulatory space relevant to the United States of America and the biomedical literature.
Gene D. Godbold, C. Matt Sharkey, Bryan T. Gemler, Craig M. Bartling, F. Curt Hewitt, Joshua C. Gil   +5 more
doaj   +1 more source