Results 21 to 30 of about 2,249,719 (290)

Do healthcare needs-based population segments predict outcomes among the elderly? Findings from a prospective cohort study in an urbanized low-income community

BMC Geriatrics, 2020
Background A rapidly ageing population with increasing prevalence of chronic disease presents policymakers the urgent task of tailoring healthcare services to optimally meet changing needs.
Jia Loon Chong, Lian Leng Low, David Bruce Matchar, Rahul Malhotra, Kheng Hock Lee, Julian Thumboo, Angelique Wei-Ming Chan   +6 more
doaj   +1 more source

Evaluating the Impact of Dropout and Genotyping Error on SNP-Based Kinship Analysis With Forensic Samples

Frontiers in Genetics, 2022
Technological advances in sequencing and single nucleotide polymorphism (SNP) genotyping microarray technology have facilitated advances in forensic analysis beyond short tandem repeat (STR) profiling, enabling the identification of unknown DNA samples ...
Stephen D. Turner, V.P. Nagraj, Matthew Scholz, Shakeel Jessa, Carlos Acevedo, Jianye Ge, Jianye Ge, August E. Woerner, August E. Woerner, Bruce Budowle, Bruce Budowle   +10 more
doaj   +1 more source

Mfsd2a-mediated lysolipid transport is important for renal recovery after acute kidney injury

Journal of Lipid Research, 2023
Acute kidney injury (AKI) is a global public health concern with high mortality and morbidity. In ischemic–reperfusion injury (IRI), a main cause of AKI, the brush border membrane of S3 proximal tubules (PT) is lost to the tubular lumen.
Randy Y.J. Loke, Cheen Fei Chin, Gao Liang, Bernice H. Wong, Dwight L.A. Galam, Bryan C. Tan, Geok-Lin Chua, Shintaro Minegishi, Norihiko Morisawa, Iulia Sidorov, Bram Heijs, Jens Titze, Markus R. Wenk, Federico Torta, David L. Silver   +14 more
doaj   +1 more source

vcferr: Development, validation, and application of a single nucleotide polymorphism genotyping error simulation framework [version 1; peer review: 1 approved, 2 approved with reservations]

F1000Research, 2022
Motivation: Genotyping error can impact downstream single nucleotide polymorphism (SNP)-based analyses. Simulating various modes and levels of error can help investigators better understand potential biases caused by miscalled genotypes. Methods: We have
Bruce Budowle, Shakeel Jessa, Jianye Ge, Stephen D. Turner, Matthew Scholz, August E. Woerner, Meng Huang, V.P. Nagraj   +7 more
doaj   +1 more source

Black holes, cosmological singularities and change of signature [PDF]

, 1994
There exists a widespread belief that signature type change could be used to avoid spacetime singularities. We show that signature change cannot be utilised to this end unless the Einstein equation is abandoned at the suface of signature type change.
Carfora M, Dereli T, Ellis G F R, Garabedian P R, Hawking S W, Hayward S A, Hayward S A, Hayward S A, Jérôme Martin, Kerner R, Kossowski M, Kossowski M, Kossowski M, Kossowski M, Kossowski M, Kossowski M, Marcus Kriele   +16 more
core   +2 more sources

Signatures and flatness.

Journal für die reine und angewandte Mathematik (Crelles Journal), 1993
Let \(Y\subset\mathbb{R}^ n\) be a codimension one analytic set, and fix a signature \(\sigma\) on \(\mathbb{R}^ n\backslash Y\) \((\sigma\) associates a \(\text{sign}+1\) or \(-1\) to each connected component of \(\mathbb{R}^ n\backslash Y)\). The signature \(\sigma\) is admissible at \(x\in Y\) when the germ \(\sigma_ x\) is induced by a germ of ...
ACQUISTAPACE, FRANCESCA, BROGLIA, FABRIZIO   +1 more
openaire   +3 more sources

Prenatal selective serotonin reuptake inhibitor (SSRI) exposure induces working memory and social recognition deficits by disrupting inhibitory synaptic networks in male mice

Molecular Brain, 2019
Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed antidepressant drugs in pregnant women. Infants born following prenatal exposure to SSRIs have a higher risk for behavioral abnormalities, however, the underlying mechanisms remains ...
Weonjin Yu, Yi-Chun Yen, Young-Hwan Lee, Shawn Tan, Yixin Xiao, Hidayat Lokman, Audrey Khoo Tze Ting, Hasini Ganegala, Taejoon Kwon, Won-Kyung Ho, H. Shawn Je   +10 more
doaj   +1 more source

SeqScreen: accurate and sensitive functional screening of pathogenic sequences via ensemble learning

Genome Biology, 2022
The COVID-19 pandemic has emphasized the importance of accurate detection of known and emerging pathogens. However, robust characterization of pathogenic sequences remains an open challenge.
Advait Balaji, Bryce Kille, Anthony D. Kappell, Gene D. Godbold, Madeline Diep, R. A. Leo Elworth, Zhiqin Qian, Dreycey Albin, Daniel J. Nasko, Nidhi Shah, Mihai Pop, Santiago Segarra, Krista L. Ternus, Todd J. Treangen   +13 more
doaj   +1 more source

Advances and Remaining Challenges in the Study of Influenza and Anthrax Infection in Lung Cell Culture

Challenges, 2018
For over 30 years, immortalized lung cells have enabled researchers to elucidate lung-pathogen molecular interactions. However, over the last five years, numerous commercial companies are now providing affordable, ready-to-use primary lung cells for use ...
Joshua D. Powell, Timothy M. Straub
doaj   +1 more source

An evaluation of the impact of aggressive hypertension, diabetes and smoking cessation management on CVD outcomes at the population level: a dynamic simulation analysis

BMC Public Health, 2019
Background Evidence from randomized control trials suggest that coupled with smoking cessation interventions, CVD events can be reduced significantly if hypertension and diabetes patients are properly managed, raising practical what-if questions at the ...
John Pastor Ansah, Ryan Leung Hoe Inn, Salman Ahmad   +2 more
doaj   +1 more source