Results 201 to 210 of about 61,304 (244)

Social Drivers of Vocal Flexibility in Female Baboons

Ethology, EarlyView.
Female olive baboons selectively grunt when encountering females with dependent offspring. Grunting likelihood depends on rank differences and the strength of their social bond. This study adds to the evidence that nonhuman primates have evolved to use structurally‐inflexible vocalisations in population and context‐flexible ways.
Yaëlle Bouquet, Eloïse C. Déaux, Jessica M. Rothman, Klaus Zuberbühler   +3 more
wiley   +1 more source

Rapid generation of a sdhb loss-of-function zebrafish model for secreting pheochromocytomas and paragangliomas. [PDF]

NPJ Genom Med
Parisien-La Salle S, Nobilleau F, da Silva Babinet A, Lamontagne J, Labrecque M, Rampal B, Mas C, Liao M, Barragan Torres VA, Corbeil G, Chatel-Chaix L, Dona M, Tétreault M, Bourdeau I, Samarut É.   +14 more
europepmc   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Translating community-wide spectral library into actionable chemical knowledge: a proof of concept with monoterpene indole alkaloids. [PDF]

J Cheminform
Szwarc S, Rutz A, Lee K, Mejri Y, Bonnet O, Hazni H, Jagora A, Mbeng Obame RB, Noh JK, Otogo N'Nang E, Alaribe SC, Awang K, Bernadat G, Choi YH, Courdavault V, Frederich M, Gaslonde T, Huber F, Kam TS, Low YY, Poupon E, van der Hooft JJJ, Kang KB, Le Pogam P, Beniddir MA.   +24 more
europepmc   +1 more source

The ALS‐associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle

The FEBS Journal, EarlyView.
DNAJC7 is a J‐domain protein that plays a key role in protein quality control by regulating Hsp70 activity and preventing protein aggregation. We find that the ALS‐associated E425K mutation in DNAJC7 disrupts productive interaction and activation of Hsp70, thereby blocking the transfer and refolding of client proteins such as TDP‐43.
Bar Elmaleh, Ofrah Faust, Rina Rosenzweig   +2 more
wiley   +1 more source

Eps2Fold: a rapid method to characterize G-quadruplex DNA structures using single absorbance spectra. [PDF]

Nucleic Acids Res
Largy E, Guédin A, Kabbara A, Mergny JL, Amrane S.   +4 more
europepmc   +1 more source

A noncanonical role for Jagged1 in endothelial mechanotransduction

The FEBS Journal, EarlyView.
This study reveals a noncanonical role for Jagged1 in endothelial mechanotransduction. Shear stress modulates Jagged1 expression and subcellular localization. Loss of Jagged1 attenuates mechanotransduction and reduces Src, VEGFR2, and ERK signaling. Direct mechanical stimulation of Jagged1 induces activation of these signaling pathways.
Freddy Suarez Rodriguez, Noora Virtanen, Elmeri Kiviluoto, Rob C. H. Driessen, Feihu Zhao, Carlijn V. C. Bouten, Oscar M. J. A. Stassen, Cecilia M. Sahlgren   +7 more
wiley   +1 more source

Pentanucleotide guanine-rich WGGGW repeats, including CANVAS AGGGA repeats, form a variety of noncanonical structures. [PDF]

Nucleic Acids Res
Wang J, Qiu D, Zhou J, Mergny JL, Alberti P.   +4 more
europepmc   +1 more source

Flexible Work Arrangements and Occupational Class: Fathers Navigating Childcare Responsibilities

Gender, Work &Organization, EarlyView.
ABSTRACT When using flexible work arrangements for caregiving, fathers risk deviating from both social expectations of breadwinning and ideal worker standards, yet implications of this divergence across different occupational classes remain unclear. Using 40 semi‐structured interviews with fathers from the Netherlands, Slovenia, Spain, and the UK, this
Carla Brega
wiley   +1 more source

Pyrite morphology and sulfur isotopes refine taphonomic models for the 2.1 Ga Francevillian biota, Gabon. [PDF]

Sci Rep
El Khoury A, Saleh F, El Albani A, Fontaine C, Rollion-Bard C, Chraiki I, Aubineau J, Ngwal'ghoubou Ikouanga J, Bhilisse M, Zguaid M, Somogyi A, Chi Fru E.   +11 more
europepmc   +1 more source