Results 31 to 40 of about 676,033 (247)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Off-line signature verification [PDF]

, 2009
In today’s society signatures are the most accepted form of identity verification. However, they have the unfortunate side-effect of being easily abused by those who would feign the identification or intent of an individual.
Larkins, Robert L.
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Cellular structures in Topology [PDF]

, 1990
This book describes the construction and the properties of CW-complexes. These spaces are important because firstly they are the correct framework for homotopy theory, and secondly most spaces that arise in pure mathematics are of this type.
Renzo Piccinini, Rudolf Fritsch, Fritsch, Rudolf, Piccinini, Renzo A., Rudolf Fritsch, et al.   +4 more
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

A new, unique signature of the true cusp [PDF]

Annales Geophysicae, 2001
The "cusp proper" is generally understood to be the region enclosed by the outermost magnetospheric field lines as they map to low altitudes. It is therefore a weak-field region with continuous contact with magnetosheath plasma.
W. R. Keith, J. D. Winningham, O. Norberg   +2 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Evidence for Exceptional Points as Topological Defects [PDF]

Quantum
Studies have shown that quantum states reside in a Hilbert space bundle. When a quantum system depends on continuous external parameters, these parameters define additional dimensions in the base space of the bundle. While much of the existing literature
Chia-Yi Ju, Szu-Ming Chen
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

New Concept Of Security E-Documents With Hybrid Method: Biometric Signature And DSA (Digital Signature Algorithm) [PDF]

, 2012
Exchange of electronic documents (e-documents) or documents in an e-mail on the internet has been widely used as a commercial transaction. To ensure e-document is still intact / authentic to the party verifier in transit on the network insecure one of ...
Ana, wahyuni
core   +1 more source